DegronMD - Q9NZT2(OGFR)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G513D	TCGA-66-2800	LUSC	TCGA	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation rewiring degron network	0.1944
p.G513D	DO27564	LUSC	ICGC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation rewiring degron network	0.1944
p.T641A	TCGA-A5-A1OF	UCEC	TCGA	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation altering degron motif	0.825
p.T641A	DO42568	UCEC	ICGC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation altering degron motif	0.825
p.K511R	TCGA-AX-A3FS	UCEC	TCGA	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation substituting flanking lysine	0.25
p.K511R	DO40879	UCEC	ICGC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation substituting flanking lysine	0.25
p.P522T	TCGA-CD-A4MG	STAD	TCGA	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.7031
p.P522T	DO48009	STAD	ICGC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.7031
p.E520Q	TCGA-D3-A8GM	SKCM	TCGA	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.5633
p.E520Q	DO50288	SKCM	ICGC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.5633
p.A530V	TCGA-DQ-5631	HNSC	TCGA	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation rewiring degron network	0.1944
p.A530V	DO14175	HNSC	ICGC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation rewiring degron network	0.1944
p.S525R	DO221164	AML	ICGC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.8538
p.S525R	DO228922	LICA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.8538
p.S525R	DO229059	LICA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.8538
p.S525R	DO218904	SKCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.8538
p.S525R	DO229264	THCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.8538
p.S525R	DO229234	THCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.8538
p.S577T	DO229003	COCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	578:585	Mutation blocking phosphorylation signal	0.75
p.S577T	DO228947	LICA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	578:585	Mutation blocking phosphorylation signal	0.75
p.S577T	DO229275	THCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	578:585	Mutation blocking phosphorylation signal	0.75
p.S577T	DO229234	THCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	578:585	Mutation blocking phosphorylation signal	0.75
p.S577T	DO229245	THCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	578:585	Mutation blocking phosphorylation signal	0.75
p.E576K	DO229003	COCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	578:585	Mutation rewiring degron network	0.2778
p.E576K	DO52365	LUSC	ICGC	PSETPGPS	DEG_SCF_FBW7_1	578:585	Mutation rewiring degron network	0.2778
p.E576K	DO229234	THCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	578:585	Mutation rewiring degron network	0.2778
p.E636K	DO233884	GACA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation rewiring degron network	0.2778
p.E636K	DO228903	LICA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation rewiring degron network	0.2778
p.E636K	DO228936	LICA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation rewiring degron network	0.2778
p.E636K	DO231061	LUSC	ICGC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation rewiring degron network	0.2778
p.E636K	DO229180	THCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation rewiring degron network	0.2778
p.E636K	DO229234	THCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation rewiring degron network	0.2778
p.E636K	HT-1080	soft tissue	COSMIC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation rewiring degron network	0.2778
p.S637T	DO228936	LICA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation blocking phosphorylation signal	0.75
p.S637T	DO231061	LUSC	ICGC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation blocking phosphorylation signal	0.75
p.S637T	DO231064	LUSC	ICGC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation blocking phosphorylation signal	0.75
p.S637T	DO231040	LUSC	ICGC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation blocking phosphorylation signal	0.75
p.S637T	DO231176	LUSC	ICGC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation blocking phosphorylation signal	0.75
p.S637T	DO229180	THCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation blocking phosphorylation signal	0.75
p.A587V	DO229259	THCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	578:585	Mutation rewiring degron network	0.2778
p.A630T	DO229242	THCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation rewiring degron network	0.1111
p.P569T	DO229250	THCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	578:585	Mutation rewiring degron network	0.0833
p.P638L	SIDM02077	Colorectal Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation altering degron motif	0.6471
p.S519L	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6556
p.S519L	SIDM00340	Plasma Cell Myeloma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6556
p.S519L	SIDM00611	Kidney Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6556
p.S519L	SIDM00416	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6556
p.S519L	SIDM00064	Hepatocellular Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6556
p.S519L	SIDM00258	Neuroblastoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6556
p.S519L	SIDM01174	Cervical Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6556
p.S519L	SIDM00496	Thyroid Gland Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6556
p.S519L	SIDM00230	Small Cell Lung Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6556
p.S519L	SIDM00287	B-Lymphoblastic Leukemia	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6556
p.S519L	SIDM00796	Head and Neck Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6556
p.S519L	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6556
p.S519L	SIDM01680	Non-Cancerous	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6556
p.S519L	SIDM01135	Pancreatic Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6556
p.S519L	SIDM00561	Other Blood Cancers	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6556
p.S519L	SIDM00920	Breast Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6556
p.S519L	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6556
p.S519L	SIDM00996	Thyroid Gland Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6556
p.S519L	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6556
p.S519L	SIDM01659	Kidney Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6556
p.S519L	SIDM01511	Gastric Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6556
p.S519L	SIDM00169	Head and Neck Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6556
p.S519L	SIDM00158	Glioblastoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6556
p.S519L	SIDM01591	Breast Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6556
p.S519L	SIDM00161	Biliary Tract Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6556
p.S519L	SIDM01445	Gastric Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6556
p.S639L	SIDM00969	Ovarian Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation altering degron motif	0.6556
p.S639L	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation altering degron motif	0.6556
p.S639L	SIDM00690	Head and Neck Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation altering degron motif	0.6556
p.S639L	SIDM00210	Ovarian Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation altering degron motif	0.6556
p.S639L	SIDM00719	Small Cell Lung Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation altering degron motif	0.6556
p.S639L	SIDM00847	Rhabdomyosarcoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation altering degron motif	0.6556
p.S639L	SIDM00493	Other Solid Cancers	GDSC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation altering degron motif	0.6556
p.S639L	SIDM00721	Small Cell Lung Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation altering degron motif	0.6556
p.S639L	SIDM00808	Burkitt's Lymphoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation altering degron motif	0.6556
p.S639L	SIDM01254	Burkitt's Lymphoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation altering degron motif	0.6556
p.S639L	SIDM01525	Acute Myeloid Leukemia	GDSC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation altering degron motif	0.6556
p.P646L	SIDM01233	Colorectal Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation rewiring degron network	0.3056
p.P646L	ACH-000009	Colon/Colorectal Cancer	CCLE	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation rewiring degron network	0.3056
p.P646L	C2BBe1	large intestine	COSMIC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation rewiring degron network	0.3056
p.G648R	SIDM00002	Neuroblastoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation rewiring degron network	0.25
p.G648R	ACH-002340	Neuroblastoma	CCLE	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation rewiring degron network	0.25
p.G648R	NBsusSR	autonomic ganglia	COSMIC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation rewiring degron network	0.25
p.E520D	SIDM00290	Gastric Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.5647
p.E520D	ACH-000847	Gastric Cancer	CCLE	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.5647
p.G523C	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6489
p.E576A	SIDM00217	Colorectal Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	578:585	Mutation rewiring degron network	0.2778
p.E576A	ACH-000182	Bile Duct Cancer	CCLE	PSETPGPS	DEG_SCF_FBW7_1	578:585	Mutation rewiring degron network	0.2778
p.E576A	ACH-000541	Myeloma	CCLE	PSETPGPS	DEG_SCF_FBW7_1	578:585	Mutation rewiring degron network	0.2778
p.E576A	ACH-000999	Colon/Colorectal Cancer	CCLE	PSETPGPS	DEG_SCF_FBW7_1	578:585	Mutation rewiring degron network	0.2778
p.E653A	SIDM01619	Endometrial Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation rewiring degron network	0.1111
p.E653A	ACH-000984	Endometrial/Uterine Cancer	CCLE	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation rewiring degron network	0.1111
p.E573K	ACH-000129	Lung Cancer	CCLE	PSETPGPS	DEG_SCF_FBW7_1	578:585	Mutation rewiring degron network	0.1944
p.P515T	ACH-000366	Neuroblastoma	CCLE	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation rewiring degron network	0.25
p.S585R	ACH-000436	Myeloma	CCLE	PSETPGPS	DEG_SCF_FBW7_1	578:585	Mutation altering degron motif	0.8538
p.S585R	ACH-000878	Lung Cancer	CCLE	PSETPGPS	DEG_SCF_FBW7_1	578:585	Mutation altering degron motif	0.8538
p.S585R	ACH-001696	Head and Neck Cancer	CCLE	PSETPGPS	DEG_SCF_FBW7_1	578:585	Mutation altering degron motif	0.8538
p.R651G	ACH-000832	Head and Neck Cancer	CCLE	PSETPGPS	DEG_SCF_FBW7_1	638:645	Mutation rewiring degron network	0.1667
p.P524S	ACH-000968	Skin Cancer	CCLE	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.5641
p.G523D	ACH-001061	Colon/Colorectal Cancer	CCLE	PSETPGPS	DEG_SCF_FBW7_1	518:525	Mutation altering degron motif	0.6087
p.D592N	ACH-002256	Leukemia	CCLE	PSETPGPS	DEG_SCF_FBW7_1	578:585	Mutation rewiring degron network	0.1389
p.E584K	HT-1080	soft tissue	COSMIC	PSETPGPS	DEG_SCF_FBW7_1	578:585	Mutation altering degron motif	0.7022
p.P594L	C2BBe1	large intestine	COSMIC	PSETPGPS	DEG_SCF_FBW7_1	578:585	Mutation rewiring degron network	0.0833
p.P574L	H-EMC-SS	bone	COSMIC	PSETPGPS	DEG_SCF_FBW7_1	578:585	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

OGFR

UniProt ID: Q9NZT2

Entrez ID: 11054

Protein name: Opioid growth factor receptor (OGFr) (Protein 7-60) (Zeta-type opioid receptor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for OGFR in