DegronMD

Uniprot ID: Q9NZT2

Source protein: Opioid growth factor receptor

Source gene: OGFR

Class: DEG_SCF_FBW7_1

Location: 518:525

E3 ligase: FBXW7

DEGRON score: 0.9925

ASA_SCORE: 93.2125

COIL: 0.9646

CONS_SCORE: 0.3838

DSS_SCORE: 0.9179

HELIX: 0.0138

FCONS_SCORE: 1.0381

RIG_SCORE: 0.4341

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G513D	TCGA-66-2800	LUSC	TCGA	PSETPGPS	DEG_SCF_FBW7_1	0.1944
p.G513D	DO27564	LUSC	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.1944
p.K511R	TCGA-AX-A3FS	UCEC	TCGA	PSETPGPS	DEG_SCF_FBW7_1	0.25
p.K511R	DO40879	UCEC	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.25
p.P522T	TCGA-CD-A4MG	STAD	TCGA	PSETPGPS	DEG_SCF_FBW7_1	0.7031
p.P522T	DO48009	STAD	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.7031
p.E520Q	TCGA-D3-A8GM	SKCM	TCGA	PSETPGPS	DEG_SCF_FBW7_1	0.5633
p.E520Q	DO50288	SKCM	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.5633
p.A530V	TCGA-DQ-5631	HNSC	TCGA	PSETPGPS	DEG_SCF_FBW7_1	0.1944
p.A530V	DO14175	HNSC	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.1944
p.S525R	DO221164	AML	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.8538
p.S525R	DO228922	LICA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.8538
p.S525R	DO229059	LICA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.8538
p.S525R	DO218904	SKCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.8538
p.S525R	DO229264	THCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.8538
p.S525R	DO229234	THCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.8538
p.S519L	SIDM01068	Non-Small Cell Lung Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S519L	SIDM00340	Plasma Cell Myeloma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S519L	SIDM00611	Kidney Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S519L	SIDM00416	B-Cell Non-Hodgkin's Lymphoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S519L	SIDM00064	Hepatocellular Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S519L	SIDM00258	Neuroblastoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S519L	SIDM01174	Cervical Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S519L	SIDM00496	Thyroid Gland Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S519L	SIDM00230	Small Cell Lung Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S519L	SIDM00287	B-Lymphoblastic Leukemia	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S519L	SIDM00796	Head and Neck Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S519L	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S519L	SIDM01680	Non-Cancerous	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S519L	SIDM01135	Pancreatic Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S519L	SIDM00561	Other Blood Cancers	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S519L	SIDM00920	Breast Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S519L	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S519L	SIDM00996	Thyroid Gland Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S519L	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S519L	SIDM01659	Kidney Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S519L	SIDM01511	Gastric Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S519L	SIDM00169	Head and Neck Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S519L	SIDM00158	Glioblastoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S519L	SIDM01591	Breast Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S519L	SIDM00161	Biliary Tract Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S519L	SIDM01445	Gastric Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.E520D	SIDM00290	Gastric Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.5647
p.E520D	ACH-000847	Gastric Cancer	CCLE	PSETPGPS	DEG_SCF_FBW7_1	0.5647
p.G523C	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6489
p.P515T	ACH-000366	Neuroblastoma	CCLE	PSETPGPS	DEG_SCF_FBW7_1	0.25
p.P524S	ACH-000968	Skin Cancer	CCLE	PSETPGPS	DEG_SCF_FBW7_1	0.5641
p.G523D	ACH-001061	Colon/Colorectal Cancer	CCLE	PSETPGPS	DEG_SCF_FBW7_1	0.6087

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSETPGPS

Degron related mutations and impact score

Drug responses associated with OGFR mutations

All proteins holding degron of PSETPGPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZT2	Opioid growth factor receptor	DEG_SCF_FBW7_1	518:525	PSETPGPS	FBXW7	0.9925	More...
Q9NZT2	Opioid growth factor receptor	DEG_SCF_FBW7_1	578:585	PSETPGPS	FBXW7	0.993	More...
Q9NZT2	Opioid growth factor receptor	DEG_SCF_FBW7_1	638:645	PSETPGPS	FBXW7	0.9817	More...