DegronMD

Uniprot ID: Q9NZT2

Source protein: Opioid growth factor receptor

Source gene: OGFR

Class: DEG_SCF_FBW7_1

Location: 578:585

E3 ligase: FBXW7

DEGRON score: 0.993

ASA_SCORE: 92.575

COIL: 0.9688

CONS_SCORE: 0.3869

DSS_SCORE: 0.936

HELIX: 0.0125

FCONS_SCORE: 1.0583

RIG_SCORE: 0.4134

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S577T	DO229003	COCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.75
p.S577T	DO228947	LICA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.75
p.S577T	DO229275	THCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.75
p.S577T	DO229234	THCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.75
p.S577T	DO229245	THCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.75
p.E576K	DO229003	COCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.2778
p.E576K	DO52365	LUSC	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.2778
p.E576K	DO229234	THCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.2778
p.A587V	DO229259	THCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.2778
p.P569T	DO229250	THCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.0833
p.E576A	SIDM00217	Colorectal Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.2778
p.E576A	ACH-000182	Bile Duct Cancer	CCLE	PSETPGPS	DEG_SCF_FBW7_1	0.2778
p.E576A	ACH-000541	Myeloma	CCLE	PSETPGPS	DEG_SCF_FBW7_1	0.2778
p.E576A	ACH-000999	Colon/Colorectal Cancer	CCLE	PSETPGPS	DEG_SCF_FBW7_1	0.2778
p.E573K	ACH-000129	Lung Cancer	CCLE	PSETPGPS	DEG_SCF_FBW7_1	0.1944
p.S585R	ACH-000436	Myeloma	CCLE	PSETPGPS	DEG_SCF_FBW7_1	0.8538
p.S585R	ACH-000878	Lung Cancer	CCLE	PSETPGPS	DEG_SCF_FBW7_1	0.8538
p.S585R	ACH-001696	Head and Neck Cancer	CCLE	PSETPGPS	DEG_SCF_FBW7_1	0.8538
p.D592N	ACH-002256	Leukemia	CCLE	PSETPGPS	DEG_SCF_FBW7_1	0.1389
p.E584K	HT-1080	soft_tissue	COSMIC	PSETPGPS	DEG_SCF_FBW7_1	0.7022
p.P594L	C2BBe1	large_intestine	COSMIC	PSETPGPS	DEG_SCF_FBW7_1	0.0833
p.P574L	H-EMC-SS	bone	COSMIC	PSETPGPS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZT2	Opioid growth factor receptor	DEG_SCF_FBW7_1	518:525	PSETPGPS	FBXW7	0.9925	More...
Q9NZT2	Opioid growth factor receptor	DEG_SCF_FBW7_1	578:585	PSETPGPS	FBXW7	0.993	More...
Q9NZT2	Opioid growth factor receptor	DEG_SCF_FBW7_1	638:645	PSETPGPS	FBXW7	0.9817	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons