DegronMD

Uniprot ID: Q9NZT2

Source protein: Opioid growth factor receptor

Source gene: OGFR

Class: DEG_SCF_FBW7_1

Location: 638:645

E3 ligase: FBXW7

DEGRON score: 0.9817

ASA_SCORE: 91.7375

COIL: 0.9708

CONS_SCORE: 0.3581

DSS_SCORE: 0.9338

HELIX: 0.0109

FCONS_SCORE: 0.9821

RIG_SCORE: 0.4309

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T641A	TCGA-A5-A1OF	UCEC	TCGA	PSETPGPS	DEG_SCF_FBW7_1	0.825
p.T641A	DO42568	UCEC	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.825
p.E636K	DO233884	GACA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.2778
p.E636K	DO228903	LICA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.2778
p.E636K	DO228936	LICA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.2778
p.E636K	DO231061	LUSC	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.2778
p.E636K	DO229180	THCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.2778
p.E636K	DO229234	THCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.2778
p.E636K	HT-1080	soft_tissue	COSMIC	PSETPGPS	DEG_SCF_FBW7_1	0.2778
p.S637T	DO228936	LICA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.75
p.S637T	DO231061	LUSC	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.75
p.S637T	DO231064	LUSC	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.75
p.S637T	DO231040	LUSC	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.75
p.S637T	DO231176	LUSC	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.75
p.S637T	DO229180	THCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.75
p.A630T	DO229242	THCA	ICGC	PSETPGPS	DEG_SCF_FBW7_1	0.1111
p.P638L	SIDM02077	Colorectal Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6471
p.S639L	SIDM00969	Ovarian Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S639L	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S639L	SIDM00690	Head and Neck Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S639L	SIDM00210	Ovarian Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S639L	SIDM00719	Small Cell Lung Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S639L	SIDM00847	Rhabdomyosarcoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S639L	SIDM00493	Other Solid Cancers	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S639L	SIDM00721	Small Cell Lung Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S639L	SIDM00808	Burkitt's Lymphoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S639L	SIDM01254	Burkitt's Lymphoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.S639L	SIDM01525	Acute Myeloid Leukemia	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.6556
p.P646L	SIDM01233	Colorectal Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.3056
p.P646L	ACH-000009	Colon/Colorectal Cancer	CCLE	PSETPGPS	DEG_SCF_FBW7_1	0.3056
p.P646L	C2BBe1	large_intestine	COSMIC	PSETPGPS	DEG_SCF_FBW7_1	0.3056
p.G648R	SIDM00002	Neuroblastoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.25
p.G648R	ACH-002340	Neuroblastoma	CCLE	PSETPGPS	DEG_SCF_FBW7_1	0.25
p.G648R	NBsusSR	autonomic_ganglia	COSMIC	PSETPGPS	DEG_SCF_FBW7_1	0.25
p.E653A	SIDM01619	Endometrial Carcinoma	GDSC	PSETPGPS	DEG_SCF_FBW7_1	0.1111
p.E653A	ACH-000984	Endometrial/Uterine Cancer	CCLE	PSETPGPS	DEG_SCF_FBW7_1	0.1111
p.R651G	ACH-000832	Head and Neck Cancer	CCLE	PSETPGPS	DEG_SCF_FBW7_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSETPGPS

Degron related mutations and impact score

Drug responses associated with OGFR mutations

All proteins holding degron of PSETPGPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NZT2	Opioid growth factor receptor	DEG_SCF_FBW7_1	518:525	PSETPGPS	FBXW7	0.9925	More...
Q9NZT2	Opioid growth factor receptor	DEG_SCF_FBW7_1	578:585	PSETPGPS	FBXW7	0.993	More...
Q9NZT2	Opioid growth factor receptor	DEG_SCF_FBW7_1	638:645	PSETPGPS	FBXW7	0.9817	More...