CIT
Entrez ID: 11113
Full name: citron rho-interacting serine/threonine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: AGC: DMPK: CRIK
Chromosomal location: 12q24.23
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
Please click HERE
for better display.
CIT
Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an importan...
Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Displays serine/threonine protein kinase activity. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.
View more >>
GO - Biological processes (BP):
actomyosin structure organization, cortical actin cytoskeleton organization, generation of neurons, intracellular signal transduction, mitotic cell cycle, mitotic cytokinesis, neuron apoptotic process, peptidyl-threonine phosphorylation, positive regulation of cytokinesis...
actomyosin structure organization, cortical actin cytoskeleton organization, generation of neurons, intracellular signal transduction, mitotic cell cycle, mitotic cytokinesis, neuron apoptotic process, peptidyl-threonine phosphorylation, positive regulation of cytokinesis
View more >>
GO - Molecular function (MF):
ATP binding, metal ion binding, PDZ domain binding, protein serine/threonine kinase activity, scaffold protein binding, SH3 domain binding...
ATP binding, metal ion binding, PDZ domain binding, protein serine/threonine kinase activity, scaffold protein binding, SH3 domain binding
View more >>
GO - Cellular component (CC):
actin cytoskeleton, cytoskeleton, cytosol, cleavage furrow, cytoplasm, membrane...
actin cytoskeleton, cytoskeleton, cytosol, cleavage furrow, cytoplasm, membrane
View more >>
citron rho-interacting serine/threonine kinase
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for CIT in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc