CDK14
Entrez ID: 5218
Full name: cyclin dependent kinase 14
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: CDK: PFTAIRE
Chromosomal location: 7q21.13
Substructure location: Gatekeeper: 210 A-loop: 273...296 G-loop: [N/A] αC-helix: [N/A]
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CDK14
Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of t...
Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.
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GO - Biological processes (BP):
cell division, G2/M transition of mitotic cell cycle, protein phosphorylation, regulation of canonical Wnt signaling pathway, Wnt signaling pathway...
cell division, G2/M transition of mitotic cell cycle, protein phosphorylation, regulation of canonical Wnt signaling pathway, Wnt signaling pathway
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GO - Molecular function (MF):
ATP binding, cyclin binding, cyclin-dependent protein serine/threonine kinase activity...
ATP binding, cyclin binding, cyclin-dependent protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, nucleoplasm, nucleus, plasma membrane, cytoplasm, cytoplasmic cyclin-dependent protein kinase holoenzyme complex...
cytosol, nucleoplasm, nucleus, plasma membrane, cytoplasm, cytoplasmic cyclin-dependent protein kinase holoenzyme complex
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cyclin dependent kinase 14
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*NOTE: the Kaplan plots were collected from OncoLnc