BMPR1A
Entrez ID: 657
Full name: bone morphogenetic protein receptor type 1A
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: STKR: STKR1
Chromosomal location: 10q23.2
Substructure location: Gatekeeper: 309 A-loop: 379...406 G-loop: [N/A] αC-helix: [N/A]
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BMPR1A
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 an...
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMP2, BMP4, GDF5 and GDF6. Positively regulates chondrocyte differentiation through GDF5 interaction. Mediates induction of adipogenesis by GDF6.
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GO - Biological processes (BP):
BMP signaling pathway, BMP signaling pathway involved in heart development, cardiac conduction system development, cardiac right ventricle morphogenesis, cellular response to BMP stimulus, cellular response to growth factor stimulus, chondrocyte differentiation, developmental growth, dorsal/ventral ...
BMP signaling pathway, BMP signaling pathway involved in heart development, cardiac conduction system development, cardiac right ventricle morphogenesis, cellular response to BMP stimulus, cellular response to growth factor stimulus, chondrocyte differentiation, developmental growth, dorsal/ventral axis specification, dorsal/ventral pattern formation, dorsal aorta morphogenesis, ectoderm development, embryonic digit morphogenesis, embryonic organ development, endocardial cushion formation, endocardial cushion morphogenesis, fibrous ring of heart morphogenesis, heart formation, hindlimb morphogenesis, immune response, in utero embryonic development, lateral mesoderm development, lung development, mesendoderm development, mesoderm formation, mitral valve morphogenesis, Mullerian duct regression, negative regulation of neurogenesis, negative regulation of smooth muscle cell migration, neural crest cell development, neural plate mediolateral regionalization, odontogenesis of dentin-containing tooth, outflow tract morphogenesis, outflow tract septum morphogenesis, paraxial mesoderm structural organization, pharyngeal arch artery morphogenesis, pituitary gland development, positive regulation of bone mineralization, positive regulation of cardiac muscle cell proliferation, positive regulation of cardiac ventricle development, positive regulation of epithelial cell proliferation, positive regulation of mesenchymal cell proliferation, positive regulation of osteoblast differentiation, positive regulation of pathway-restricted SMAD protein phosphorylation, positive regulation of pri-miRNA transcription by RNA polymerase II, positive regulation of SMAD protein signal transduction, positive regulation of transcription by RNA polymerase II, positive regulation of vascular smooth muscle cell proliferation, protein phosphorylation, regulation of cardiac muscle cell proliferation, regulation of cellular senescence, regulation of lateral mesodermal cell fate specification, roof of mouth development, somitogenesis, stem cell population maintenance, transforming growth factor beta receptor signaling pathway, tricuspid valve morphogenesis, ventricular compact myocardium morphogenesis, ventricular trabecula myocardium morphogenesis
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GO - Molecular function (MF):
ATP binding, BMP receptor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, protein homodimerization activity, protein serine/threonine kinase activity, SMAD binding, transforming growth factor beta receptor activity, type I, transmembrane receptor p...
ATP binding, BMP receptor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, metal ion binding, protein homodimerization activity, protein serine/threonine kinase activity, SMAD binding, transforming growth factor beta receptor activity, type I, transmembrane receptor protein serine/threonine kinase activity
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GO - Cellular component (CC):
external side of plasma membrane, HFE-transferrin receptor complex, plasma membrane, dendrite, integral component of membrane, neuronal cell body, receptor complex...
external side of plasma membrane, HFE-transferrin receptor complex, plasma membrane, dendrite, integral component of membrane, neuronal cell body, receptor complex
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bone morphogenetic protein receptor type 1A
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Kaplan plot for BMPR1A in
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*NOTE: the Kaplan plots were collected from OncoLnc