ACVRL1
Entrez ID: 94
Full name: activin A receptor like type 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: STKR: STKR1
Chromosomal location: 12q13.13
Substructure location: Gatekeeper: 277 A-loop: 347...374 G-loop: 209...216 αC-helix: 233...235
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ACVRL1
Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I...
Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.
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GO - Biological processes (BP):
angiogenesis, artery development, blood circulation, blood vessel endothelial cell proliferation involved in sprouting angiogenesis, blood vessel maturation, blood vessel remodeling, BMP signaling pathway, cellular response to BMP stimulus, cellular response to growth factor stimulus, cellular respo...
angiogenesis, artery development, blood circulation, blood vessel endothelial cell proliferation involved in sprouting angiogenesis, blood vessel maturation, blood vessel remodeling, BMP signaling pathway, cellular response to BMP stimulus, cellular response to growth factor stimulus, cellular response to transforming growth factor beta stimulus, dorsal aorta morphogenesis, endocardial cushion morphogenesis, endothelial tube morphogenesis, heart development, in utero embryonic development, lymphangiogenesis, lymphatic endothelial cell differentiation, negative regulation of blood vessel endothelial cell migration, negative regulation of cell adhesion, negative regulation of cell growth, negative regulation of cell migration, negative regulation of cell population proliferation, negative regulation of DNA biosynthetic process, negative regulation of endothelial cell differentiation, negative regulation of endothelial cell migration, negative regulation of endothelial cell proliferation, negative regulation of focal adhesion assembly, negative regulation of gene expression, positive regulation of angiogenesis, positive regulation of BMP signaling pathway, positive regulation of chondrocyte differentiation, positive regulation of endothelial cell differentiation, positive regulation of endothelial cell proliferation, positive regulation of pathway-restricted SMAD protein phosphorylation, positive regulation of transcription, DNA-templated, positive regulation of transcription by RNA polymerase II, protein phosphorylation, regulation of blood pressure, regulation of blood vessel endothelial cell migration, regulation of DNA replication, regulation of endothelial cell proliferation, regulation of transcription, DNA-templated, response to hypoxia, retina vasculature development in camera-type eye, signal transduction, transforming growth factor beta receptor signaling pathway, venous blood vessel development, wound healing, spreading of epidermal cells
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GO - Molecular function (MF):
activin binding, activin receptor activity, type I, ATP binding, BMP receptor activity, metal ion binding, protein kinase binding, protein serine/threonine kinase activity, SMAD binding, transforming growth factor beta-activated receptor activity, transforming growth factor beta binding, transformin...
activin binding, activin receptor activity, type I, ATP binding, BMP receptor activity, metal ion binding, protein kinase binding, protein serine/threonine kinase activity, SMAD binding, transforming growth factor beta-activated receptor activity, transforming growth factor beta binding, transforming growth factor beta receptor activity, type I, transmembrane receptor protein serine/threonine kinase activity
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GO - Cellular component (CC):
BMP receptor complex, integral component of plasma membrane, plasma membrane, cell surface, dendrite, neuronal cell body, receptor complex...
BMP receptor complex, integral component of plasma membrane, plasma membrane, cell surface, dendrite, neuronal cell body, receptor complex
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activin A receptor like type 1
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Kaplan plot for ACVRL1 in
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*NOTE: the Kaplan plots were collected from OncoLnc