BLK
Entrez ID: 640
Full name: BLK proto-oncogene, Src family tyrosine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: Src: SrcB
Chromosomal location: 8p23.1
Substructure location: Gatekeeper: 312 A-loop: [N/A] G-loop: [N/A] αC-helix: [N/A]
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BLK
Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling (By similarity). B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors (By similarity). Binding of antigen to the B-...
Non-receptor tyrosine kinase involved in B-lymphocyte development, differentiation and signaling (By similarity). B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors (By similarity). Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation (By similarity). Signaling through BLK plays an important role in transmitting signals through surface immunoglobulins and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor (By similarity). Specifically binds and phosphorylates CD79A at 'Tyr-188'and 'Tyr-199', as well as CD79B at 'Tyr-196' and 'Tyr-207' (By similarity). Phosphorylates also the immunoglobulin G receptors FCGR2A, FCGR2B and FCGR2C (PubMed:8756631). With FYN and LYN, plays an essential role in pre-B-cell receptor (pre-BCR)-mediated NF-kappa-B activation (By similarity). Contributes also to BTK activation by indirectly stimulating BTK intramolecular autophosphorylation (By similarity). In pancreatic islets, acts as a modulator of beta-cells function through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose (PubMed:19667185). Phosphorylates CGAS, promoting retention of CGAS in the cytosol (PubMed:30356214).
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GO - Biological processes (BP):
B cell receptor signaling pathway, cell differentiation, intracellular signal transduction, peptidyl-tyrosine autophosphorylation, peptidyl-tyrosine phosphorylation, positive regulation of insulin secretion, regulation of B cell receptor signaling pathway, regulation of cell population proliferation...
B cell receptor signaling pathway, cell differentiation, intracellular signal transduction, peptidyl-tyrosine autophosphorylation, peptidyl-tyrosine phosphorylation, positive regulation of insulin secretion, regulation of B cell receptor signaling pathway, regulation of cell population proliferation, transmembrane receptor protein tyrosine kinase signaling pathway
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GO - Molecular function (MF):
ATP binding, non-membrane spanning protein tyrosine kinase activity, protein tyrosine kinase activity, signaling receptor binding...
ATP binding, non-membrane spanning protein tyrosine kinase activity, protein tyrosine kinase activity, signaling receptor binding
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GO - Cellular component (CC):
cytosol, extrinsic component of cytoplasmic side of plasma membrane...
cytosol, extrinsic component of cytoplasmic side of plasma membrane
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BLK proto-oncogene, Src family tyrosine kinase
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Kaplan plot for BLK in
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*NOTE: the Kaplan plots were collected from OncoLnc