MAP3K10
Entrez ID: 4294
Full name: mitogen-activated protein kinase kinase kinase 10
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: MLK: MLK
Chromosomal location: 19q13.2
Substructure location: Gatekeeper: [N/A] A-loop: 247...268 G-loop: [N/A] αC-helix: [N/A]
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MAP3K10
Activates the JUN N-terminal pathway....
Activates the JUN N-terminal pathway.
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GO - Biological processes (BP):
activation of JUN kinase activity, apoptotic process, JNK cascade, negative regulation of DNA-binding transcription factor activity, negative regulation of transcription, DNA-templated, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation of apoptotic process, pos...
activation of JUN kinase activity, apoptotic process, JNK cascade, negative regulation of DNA-binding transcription factor activity, negative regulation of transcription, DNA-templated, peptidyl-serine phosphorylation, peptidyl-threonine phosphorylation, positive regulation of apoptotic process, positive regulation of JNK cascade, positive regulation of JUN kinase activity, protein autophosphorylation, signal transduction, smoothened signaling pathway
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GO - Molecular function (MF):
ATP binding, bHLH transcription factor binding, JUN kinase kinase kinase activity, protein homodimerization activity, protein kinase activity, protein serine/threonine kinase activity, transcription corepressor activity...
ATP binding, bHLH transcription factor binding, JUN kinase kinase kinase activity, protein homodimerization activity, protein kinase activity, protein serine/threonine kinase activity, transcription corepressor activity
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GO - Cellular component (CC):
cytoplasm...
cytoplasm
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mitogen-activated protein kinase kinase kinase 10
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αC-helix
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Minimum 5 samples
Minimum 10 samples
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Kaplan plot for MAP3K10 in
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*NOTE: the Kaplan plots were collected from OncoLnc