DDR1
Entrez ID: 780
Full name: discoidin domain receptor tyrosine kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: DDR
Chromosomal location: 6p21.33
Substructure location: Gatekeeper: 701 A-loop: 783...808 G-loop: 617...624 αC-helix: 632...634
Please click HERE
for better display.
DDR1
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that invol...
Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
View more >>
GO - Biological processes (BP):
axon development, branching involved in mammary gland duct morphogenesis, cell adhesion, collagen-activated tyrosine kinase receptor signaling pathway, ear development, embryo implantation, extracellular matrix organization, lactation, mammary gland alveolus development, multicellular organism devel...
axon development, branching involved in mammary gland duct morphogenesis, cell adhesion, collagen-activated tyrosine kinase receptor signaling pathway, ear development, embryo implantation, extracellular matrix organization, lactation, mammary gland alveolus development, multicellular organism development, negative regulation of cell population proliferation, neuron projection extension, peptidyl-tyrosine autophosphorylation, positive regulation of kinase activity, protein autophosphorylation, regulation of cell growth, regulation of cell-matrix adhesion, regulation of extracellular matrix disassembly, smooth muscle cell-matrix adhesion, smooth muscle cell migration, transmembrane receptor protein tyrosine kinase signaling pathway, wound healing, spreading of cells
View more >>
GO - Molecular function (MF):
ATP binding, collagen binding, metal ion binding, protein tyrosine kinase collagen receptor activity, transmembrane receptor protein tyrosine kinase activity...
ATP binding, collagen binding, metal ion binding, protein tyrosine kinase collagen receptor activity, transmembrane receptor protein tyrosine kinase activity
View more >>
GO - Cellular component (CC):
extracellular exosome, extracellular space, integral component of plasma membrane, plasma membrane, receptor complex...
extracellular exosome, extracellular space, integral component of plasma membrane, plasma membrane, receptor complex
View more >>
discoidin domain receptor tyrosine kinase 1
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for DDR1 in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc