MAP3K1
Entrez ID: 4214
Full name: mitogen-activated protein kinase kinase kinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE11: MEKK1
Chromosomal location: 5q11.2
Substructure location: Gatekeeper: 1323 A-loop: 1387...1414 G-loop: [N/A] αC-helix: [N/A]
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MAP3K1
Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-k...
Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624).
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GO - Biological processes (BP):
activation of protein kinase activity, cellular response to mechanical stimulus, Fc-epsilon receptor signaling pathway, MyD88-dependent toll-like receptor signaling pathway, protein phosphorylation, regulation of mitotic cell cycle, signal transduction by protein phosphorylation, stress-activated pr...
activation of protein kinase activity, cellular response to mechanical stimulus, Fc-epsilon receptor signaling pathway, MyD88-dependent toll-like receptor signaling pathway, protein phosphorylation, regulation of mitotic cell cycle, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade
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GO - Molecular function (MF):
ATP binding, MAP kinase kinase kinase activity, protein kinase activity, protein kinase binding, protein serine/threonine kinase activity, zinc ion binding...
ATP binding, MAP kinase kinase kinase activity, protein kinase activity, protein kinase binding, protein serine/threonine kinase activity, zinc ion binding
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GO - Cellular component (CC):
cytosol, cytoplasm...
cytosol, cytoplasm
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mitogen-activated protein kinase kinase kinase 1
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*NOTE: the Kaplan plots were collected from OncoLnc