CAMK2B
Entrez ID: 816
Full name: calcium/calmodulin dependent protein kinase II beta
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: CAMK2
Chromosomal location: 7p13
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: [N/A] αC-helix: 52...67
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CAMK2B
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays a...
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle. In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089). Participates in the modulation of skeletal muscle function in response to exercise. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitch muscle participates in the control of Ca2+ release from the SR through phosphorylation of triadin, a ryanodine receptor-coupling factor, and phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2.
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GO - Biological processes (BP):
interferon-gamma-mediated signaling pathway, positive regulation of dendritic spine morphogenesis, positive regulation of neuron projection development, positive regulation of synapse maturation, protein autophosphorylation, protein phosphorylation, regulation of calcium ion transport, regulation of...
interferon-gamma-mediated signaling pathway, positive regulation of dendritic spine morphogenesis, positive regulation of neuron projection development, positive regulation of synapse maturation, protein autophosphorylation, protein phosphorylation, regulation of calcium ion transport, regulation of cellular response to heat, regulation of dendritic spine development, regulation of long-term neuronal synaptic plasticity, regulation of neuron migration, regulation of skeletal muscle adaptation, regulation of synapse structural plasticity, signal transduction
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GO - Molecular function (MF):
actin binding, ATP binding, calmodulin binding, calmodulin-dependent protein kinase activity, identical protein binding, protein homodimerization activity...
actin binding, ATP binding, calmodulin binding, calmodulin-dependent protein kinase activity, identical protein binding, protein homodimerization activity
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GO - Cellular component (CC):
microtubule organizing center, cytosol, sarcoplasmic reticulum membrane, nucleoplasm, calcium- and calmodulin-dependent protein kinase complex, cell junction, cytoplasm, endocytic vesicle membrane, neuron projection, synapse...
microtubule organizing center, cytosol, sarcoplasmic reticulum membrane, nucleoplasm, calcium- and calmodulin-dependent protein kinase complex, cell junction, cytoplasm, endocytic vesicle membrane, neuron projection, synapse
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calcium/calmodulin dependent protein kinase II beta
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Kaplan plot for CAMK2B in
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*NOTE: the Kaplan plots were collected from OncoLnc