CDK13
Entrez ID: 8621
Full name: cyclin dependent kinase 13
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CMGC: CDK: CRK7
Chromosomal location: 7p14.1
Substructure location: Gatekeeper: 791 A-loop: 854...866, 868...878 G-loop: 711...717 αC-helix: 747...758
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CDK13
Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. R...
Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef.
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GO - Biological processes (BP):
alternative mRNA splicing, via spliceosome, hemopoiesis, multicellular organism development, negative regulation of stem cell differentiation, neutrophil degranulation, phosphorylation of RNA polymerase II C-terminal domain, positive regulation of cell population proliferation, positive regulation o...
alternative mRNA splicing, via spliceosome, hemopoiesis, multicellular organism development, negative regulation of stem cell differentiation, neutrophil degranulation, phosphorylation of RNA polymerase II C-terminal domain, positive regulation of cell population proliferation, positive regulation of transcription by RNA polymerase II, positive regulation of transcription elongation from RNA polymerase II promoter, protein phosphorylation, regulation of mitotic nuclear division, transcription elongation from RNA polymerase II promoter, viral process
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GO - Molecular function (MF):
ATP binding, cyclin binding, cyclin-dependent protein serine/threonine kinase activity, protein kinase activity, protein kinase binding, RNA binding, RNA polymerase II CTD heptapeptide repeat kinase activity, transcription factor binding, transcription regulatory region DNA binding...
ATP binding, cyclin binding, cyclin-dependent protein serine/threonine kinase activity, protein kinase activity, protein kinase binding, RNA binding, RNA polymerase II CTD heptapeptide repeat kinase activity, transcription factor binding, transcription regulatory region DNA binding
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GO - Cellular component (CC):
cytosol, extracellular region, extracellular space, Golgi apparatus, cyclin/CDK positive transcription elongation factor complex, nuclear chromatin, nuclear cyclin-dependent protein kinase holoenzyme complex, nuclear speck, nucleoplasm, nucleus, chromosome, cyclin K-CDK13 complex, cyclin-dependent p...
cytosol, extracellular region, extracellular space, Golgi apparatus, cyclin/CDK positive transcription elongation factor complex, nuclear chromatin, nuclear cyclin-dependent protein kinase holoenzyme complex, nuclear speck, nucleoplasm, nucleus, chromosome, cyclin K-CDK13 complex, cyclin-dependent protein kinase holoenzyme complex, ficolin-1-rich granule lumen
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cyclin dependent kinase 13
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*NOTE: the Kaplan plots were collected from OncoLnc