DDR2
Entrez ID: 4921
Full name: discoidin domain receptor tyrosine kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TK: DDR
Chromosomal location: 1q23.3
Substructure location: Gatekeeper: 654 A-loop: 727...752 G-loop: [N/A] αC-helix: [N/A]
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DDR2
Tyrosine kinase involved in the regulation of tissues remodeling (PubMed:30449416). It functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Re...
Tyrosine kinase involved in the regulation of tissues remodeling (PubMed:30449416). It functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.
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GO - Biological processes (BP):
biomineral tissue development, cell adhesion, chondrocyte proliferation, collagen-activated tyrosine kinase receptor signaling pathway, collagen fibril organization, endochondral bone growth, extracellular matrix organization, multicellular organism development, ossification, peptidyl-tyrosine phosp...
biomineral tissue development, cell adhesion, chondrocyte proliferation, collagen-activated tyrosine kinase receptor signaling pathway, collagen fibril organization, endochondral bone growth, extracellular matrix organization, multicellular organism development, ossification, peptidyl-tyrosine phosphorylation, positive regulation of DNA-binding transcription factor activity, positive regulation of extracellular matrix disassembly, positive regulation of fibroblast migration, positive regulation of fibroblast proliferation, positive regulation of kinase activity, positive regulation of osteoblast differentiation, positive regulation of protein kinase activity, protein autophosphorylation, regulation of bone mineralization, regulation of extracellular matrix disassembly, regulation of tissue remodeling, signal transduction, transmembrane receptor protein tyrosine kinase signaling pathway
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GO - Molecular function (MF):
ATP binding, collagen binding, protein tyrosine kinase collagen receptor activity, transmembrane receptor protein tyrosine kinase activity...
ATP binding, collagen binding, protein tyrosine kinase collagen receptor activity, transmembrane receptor protein tyrosine kinase activity
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GO - Cellular component (CC):
actin cytoskeleton, apical plasma membrane, integral component of plasma membrane, plasma membrane, focal adhesion, receptor complex...
actin cytoskeleton, apical plasma membrane, integral component of plasma membrane, plasma membrane, focal adhesion, receptor complex
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discoidin domain receptor tyrosine kinase 2
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*NOTE: the Kaplan plots were collected from OncoLnc