SCYL2
Entrez ID: 55681
Full name: SCY1 like pseudokinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: SCY1
Chromosomal location: 12q23.1
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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SCYL2
Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro, the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in pres...
Component of AP2-containing clathrin coated structures at the plasma membrane or of endocytic coated vesicles. According to PubMed:15809293, probable serine/threonine-protein kinase that phosphorylates, in vitro, the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine. According to PubMed:16914521, has no detectable kinase activity in vitro. May regulate clathrin-dependent trafficking between the TGN and/or the endosomal system.
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GO - Biological processes (BP):
endosome to lysosome transport, negative regulation of canonical Wnt signaling pathway, positive regulation of clathrin-dependent endocytosis, positive regulation of receptor internalization, receptor internalization involved in canonical Wnt signaling pathway...
endosome to lysosome transport, negative regulation of canonical Wnt signaling pathway, positive regulation of clathrin-dependent endocytosis, positive regulation of receptor internalization, receptor internalization involved in canonical Wnt signaling pathway
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GO - Molecular function (MF):
ATP binding, protein kinase activity, signaling receptor binding...
ATP binding, protein kinase activity, signaling receptor binding
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GO - Cellular component (CC):
endosome membrane, Golgi apparatus, clathrin-coated vesicle, perinuclear region of cytoplasm...
endosome membrane, Golgi apparatus, clathrin-coated vesicle, perinuclear region of cytoplasm
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SCY1 like pseudokinase 2
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Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
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Minimum 5 samples
Minimum 10 samples
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Kaplan plot for SCYL2 in
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*NOTE: the Kaplan plots were collected from OncoLnc