ULK3
Entrez ID: 25989
Full name: unc-51 like kinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: ULK: ULK
Chromosomal location: 15q24.1
Substructure location: Gatekeeper: 91 A-loop: 156...166, 168...178 G-loop: [N/A] αC-helix: [N/A]
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ULK3
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (...
Serine/threonine protein kinase that acts as a regulator of Sonic hedgehog (SHH) signaling and autophagy. Acts as a negative regulator of SHH signaling in the absence of SHH ligand: interacts with SUFU, thereby inactivating the protein kinase activity and preventing phosphorylation of GLI proteins (GLI1, GLI2 and/or GLI3). Positively regulates SHH signaling in the presence of SHH: dissociates from SUFU, autophosphorylates and mediates phosphorylation of GLI2, activating it and promoting its nuclear translocation. Phosphorylates in vitro GLI2, as well as GLI1 and GLI3, although less efficiently. Also acts as a regulator of autophagy: following cellular senescence, able to induce autophagy.
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GO - Biological processes (BP):
autophagy, cellular senescence, fibroblast activation, negative regulation of smoothened signaling pathway, positive regulation of smoothened signaling pathway, protein autophosphorylation...
autophagy, cellular senescence, fibroblast activation, negative regulation of smoothened signaling pathway, positive regulation of smoothened signaling pathway, protein autophosphorylation
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GO - Molecular function (MF):
ATP binding, protein serine/threonine kinase activity...
ATP binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
ciliary tip, cytoplasm, phagophore assembly site...
ciliary tip, cytoplasm, phagophore assembly site
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unc-51 like kinase 3
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Kaplan plot for ULK3 in
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*NOTE: the Kaplan plots were collected from OncoLnc