PIM3
Entrez ID: 415116
Full name: Pim-3 proto-oncogene, serine/threonine kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: PIM
Chromosomal location: 22q13.33
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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PIM3
Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the...
Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth.
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GO - Biological processes (BP):
apoptotic process, cell cycle, negative regulation of apoptotic process, negative regulation of insulin secretion involved in cellular response to glucose stimulus, protein autophosphorylation, protein phosphorylation, regulation of mitotic cell cycle...
apoptotic process, cell cycle, negative regulation of apoptotic process, negative regulation of insulin secretion involved in cellular response to glucose stimulus, protein autophosphorylation, protein phosphorylation, regulation of mitotic cell cycle
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GO - Molecular function (MF):
ATP binding, protein serine/threonine kinase activity...
ATP binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, cytoplasm...
cytosol, cytoplasm
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Pim-3 proto-oncogene, serine/threonine kinase
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αC-helix
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*NOTE: the Kaplan plots were collected from OncoLnc