BRSK2
Entrez ID: 9024
Full name: BR serine/threonine kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: CAMKL: BRSK
Chromosomal location: 11p15.5
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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BRSK2
Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cort...
Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion (PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion (PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmic reticulum (ER) stress.
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GO - Biological processes (BP):
actin cytoskeleton reorganization, axonogenesis, cell division, ERAD pathway, establishment of cell polarity, exocytosis, G2/M transition of mitotic cell cycle, intracellular signal transduction, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, microtubule cytoskele...
actin cytoskeleton reorganization, axonogenesis, cell division, ERAD pathway, establishment of cell polarity, exocytosis, G2/M transition of mitotic cell cycle, intracellular signal transduction, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, microtubule cytoskeleton organization involved in establishment of planar polarity, neuron differentiation, peptidyl-serine phosphorylation, protein phosphorylation, regulation of ATPase activity, regulation of axonogenesis, regulation of insulin secretion involved in cellular response to glucose stimulus, regulation of neuron projection development, regulation of retrograde protein transport, ER to cytosol, regulation of synaptic vesicle clustering
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GO - Molecular function (MF):
ATPase binding, ATPase regulator activity, ATP binding, magnesium ion binding, protein kinase binding, protein serine/threonine kinase activity, tau protein binding, tau-protein kinase activity...
ATPase binding, ATPase regulator activity, ATP binding, magnesium ion binding, protein kinase binding, protein serine/threonine kinase activity, tau protein binding, tau-protein kinase activity
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GO - Cellular component (CC):
centrosome, endoplasmic reticulum, nucleus, cytoplasm, distal axon, perinuclear region of cytoplasm...
centrosome, endoplasmic reticulum, nucleus, cytoplasm, distal axon, perinuclear region of cytoplasm
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BR serine/threonine kinase 2
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Kaplan plot for BRSK2 in
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*NOTE: the Kaplan plots were collected from OncoLnc