ACVR1C
Entrez ID: 130399
Full name: activin A receptor type 1C
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: STKR: STKR1
Chromosomal location: 2q24.1
Substructure location: Gatekeeper: 270 A-loop: 340...367 G-loop: [N/A] αC-helix: [N/A]
Please click HERE
for better display.
ACVR1C
Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD trans...
Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
View more >>
GO - Biological processes (BP):
activin receptor signaling pathway, apoptotic nuclear changes, cell differentiation, cellular response to growth factor stimulus, lipid storage, negative regulation of chorionic trophoblast cell proliferation, negative regulation of insulin secretion, negative regulation of trophoblast cell migratio...
activin receptor signaling pathway, apoptotic nuclear changes, cell differentiation, cellular response to growth factor stimulus, lipid storage, negative regulation of chorionic trophoblast cell proliferation, negative regulation of insulin secretion, negative regulation of trophoblast cell migration, nervous system development, nodal signaling pathway, positive regulation of apoptotic process, positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, protein phosphorylation, response to dietary excess, response to glucose, response to insulin, trophectodermal cell proliferation
View more >>
GO - Molecular function (MF):
activin receptor activity, type I, ATP binding, growth factor binding, metal ion binding, nodal binding, protein serine/threonine kinase activity...
activin receptor activity, type I, ATP binding, growth factor binding, metal ion binding, nodal binding, protein serine/threonine kinase activity
View more >>
GO - Cellular component (CC):
activin receptor complex, plasma membrane, receptor complex...
activin receptor complex, plasma membrane, receptor complex
View more >>
activin A receptor type 1C
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for ACVR1C in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc