COQ8A
Entrez ID: 56997
Full name: coenzyme Q8A
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Atypical: ABC1: ABC1-A
Chromosomal location: 1q42.13
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
Please click HERE
for better display.
COQ8A
Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:25498144, PubMed:21296186, PubMed:25540914, PubMed:27499294). Its substrate specificity is unclear: does not show any protein ki...
Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:25498144, PubMed:21296186, PubMed:25540914, PubMed:27499294). Its substrate specificity is unclear: does not show any protein kinase activity (PubMed:25498144, PubMed:27499294). Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway, as suggested by its ability to bind coenzyme Q lipid intermediates (PubMed:25498144, PubMed:27499294). Shows an unusual selectivity for binding ADP over ATP (PubMed:25498144).
View more >>
GO - Biological processes (BP):
phosphorylation, protein phosphorylation, ubiquinone biosynthetic process...
phosphorylation, protein phosphorylation, ubiquinone biosynthetic process
View more >>
GO - Molecular function (MF):
ADP binding, ATP binding, kinase activity...
ADP binding, ATP binding, kinase activity
View more >>
GO - Cellular component (CC):
extrinsic component of mitochondrial inner membrane, mitochondrion, integral component of membrane...
extrinsic component of mitochondrial inner membrane, mitochondrion, integral component of membrane
View more >>
coenzyme Q8A
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for COQ8A in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc