MASTL
Entrez ID: 84930
Full name: microtubule associated serine/threonine kinase like
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: AGC: MAST: MASTL
Chromosomal location: 10p12.1
Substructure location: Gatekeeper: 110 A-loop: [N/A] G-loop: [N/A] αC-helix: 118...125
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MASTL
Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of AR...
Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.
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GO - Biological processes (BP):
cell division, cellular response to DNA damage stimulus, female meiosis II, G2/M transition of mitotic cell cycle, intracellular signal transduction, mitotic cell cycle, negative regulation of phosphoprotein phosphatase activity, peptidyl-serine phosphorylation, positive regulation of ubiquitin prot...
cell division, cellular response to DNA damage stimulus, female meiosis II, G2/M transition of mitotic cell cycle, intracellular signal transduction, mitotic cell cycle, negative regulation of phosphoprotein phosphatase activity, peptidyl-serine phosphorylation, positive regulation of ubiquitin protein ligase activity, regulation of cell cycle
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GO - Molecular function (MF):
ATP binding, kinase activity, protein phosphatase 2A binding, protein serine/threonine kinase activity...
ATP binding, kinase activity, protein phosphatase 2A binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
centrosome, nucleoplasm, nucleus, cleavage furrow, cytoplasm...
centrosome, nucleoplasm, nucleus, cleavage furrow, cytoplasm
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microtubule associated serine/threonine kinase like
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Kaplan plot for MASTL in
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*NOTE: the Kaplan plots were collected from OncoLnc