TRIB3
Entrez ID: 57761
Full name: tribbles pseudokinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: Trbl
Chromosomal location: 20p13
Substructure location: Gatekeeper: 129 A-loop: [N/A] G-loop: [N/A] αC-helix: [N/A]
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TRIB3
Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibit...
Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA.
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GO - Biological processes (BP):
cellular response to insulin stimulus, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, negative regulation of fat cell differentiation, negative regulation of fatty acid biosynthetic process, negative regulation of protein kinase activity, negative regulation of pr...
cellular response to insulin stimulus, intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress, negative regulation of fat cell differentiation, negative regulation of fatty acid biosynthetic process, negative regulation of protein kinase activity, negative regulation of protein kinase B signaling, negative regulation of transcription, DNA-templated, negative regulation of transcription by RNA polymerase II, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, positive regulation of protein binding, positive regulation of ubiquitin-protein transferase activity, protein phosphorylation, regulation of autophagy, regulation of glucose transmembrane transport, regulation of lipid metabolic process, regulation of MAP kinase activity, response to endoplasmic reticulum stress
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GO - Molecular function (MF):
ATP binding, mitogen-activated protein kinase kinase binding, protein kinase binding, protein kinase inhibitor activity, transcription corepressor activity, ubiquitin protein ligase binding, ubiquitin-protein transferase regulator activity...
ATP binding, mitogen-activated protein kinase kinase binding, protein kinase binding, protein kinase inhibitor activity, transcription corepressor activity, ubiquitin protein ligase binding, ubiquitin-protein transferase regulator activity
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GO - Cellular component (CC):
cytosol, nucleoplasm, nucleus, plasma membrane...
cytosol, nucleoplasm, nucleus, plasma membrane
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tribbles pseudokinase 3
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Kaplan plot for TRIB3 in
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*NOTE: the Kaplan plots were collected from OncoLnc