TRIB1
Entrez ID: 10221
Full name: tribbles pseudokinase 1
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: Trbl
Chromosomal location: 8q24.13
Substructure location: Gatekeeper: 152 A-loop: [N/A] G-loop: [N/A] αC-helix: 124...130
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TRIB1
Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596). The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter COP1 substrate specificity by directing the activity of COP1 ...
Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase (PubMed:27041596). The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain (PubMed:26455797). Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA (PubMed:27041596). Binds selectively the recognition sequence of CEBPA (PubMed:26455797). Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner (By similarity). Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain (By similarity). Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity (PubMed:15299019, PubMed:26455797).
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GO - Biological processes (BP):
JNK cascade, negative regulation of DNA-binding transcription factor activity, negative regulation of lipopolysaccharide-mediated signaling pathway, negative regulation of neutrophil differentiation, negative regulation of protein kinase activity, negative regulation of smooth muscle cell migration,...
JNK cascade, negative regulation of DNA-binding transcription factor activity, negative regulation of lipopolysaccharide-mediated signaling pathway, negative regulation of neutrophil differentiation, negative regulation of protein kinase activity, negative regulation of smooth muscle cell migration, negative regulation of smooth muscle cell proliferation, positive regulation of eosinophil differentiation, positive regulation of macrophage differentiation, positive regulation of proteasomal ubiquitin-dependent protein catabolic process, regulation of MAP kinase activity, response to lipopolysaccharide
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GO - Molecular function (MF):
mitogen-activated protein kinase kinase binding, protein kinase inhibitor activity, transcription factor binding, ubiquitin protein ligase binding, ubiquitin-protein transferase regulator activity...
mitogen-activated protein kinase kinase binding, protein kinase inhibitor activity, transcription factor binding, ubiquitin protein ligase binding, ubiquitin-protein transferase regulator activity
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GO - Cellular component (CC):
nucleus, cytoplasm...
nucleus, cytoplasm
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tribbles pseudokinase 1
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Kaplan plot for TRIB1 in
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*NOTE: the Kaplan plots were collected from OncoLnc