MAP3K3
Entrez ID: 4215
Full name: mitogen-activated protein kinase kinase kinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE11: MEKK2
Chromosomal location: 17q23.3
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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MAP3K3
Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators....
Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.
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GO - Biological processes (BP):
activation of protein kinase activity, blood vessel development, interleukin-1-mediated signaling pathway, intracellular signal transduction, MAPK cascade, negative regulation of cellular senescence, positive regulation of cell migration involved in sprouting angiogenesis, positive regulation of cel...
activation of protein kinase activity, blood vessel development, interleukin-1-mediated signaling pathway, intracellular signal transduction, MAPK cascade, negative regulation of cellular senescence, positive regulation of cell migration involved in sprouting angiogenesis, positive regulation of cell proliferation in bone marrow, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of p38MAPK cascade, protein autophosphorylation, regulation of mitotic cell cycle, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade
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GO - Molecular function (MF):
ATP binding, MAP kinase kinase kinase activity, metal ion binding, protein kinase activity, protein serine/threonine kinase activity...
ATP binding, MAP kinase kinase kinase activity, metal ion binding, protein kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, cytoplasm...
cytosol, cytoplasm
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mitogen-activated protein kinase kinase kinase 3
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A-loop
G-loop
αC-helix
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A-loop
G-loop
αC-helix
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Minimum 10 samples
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Kaplan plot for MAP3K3 in
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*NOTE: the Kaplan plots were collected from OncoLnc