WNK3
Entrez ID: 65267
Full name: WNK lysine deficient protein kinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: WNK
Chromosomal location: Xp11.22
Substructure location: Gatekeeper: 227 A-loop: 293...314 G-loop: [N/A] αC-helix: [N/A]
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WNK3
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:16275913, Pu...
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively (PubMed:16275913, PubMed:16275911, PubMed:16357011). Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca2+ influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway (PubMed:18768590). Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner.
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GO - Biological processes (BP):
cell volume homeostasis, intracellular signal transduction, ion homeostasis, maintenance of permeability of blood-brain barrier, negative regulation of apoptotic process, negative regulation of pancreatic juice secretion, negative regulation of sodium ion transport, osmosensory signaling pathway, pe...
cell volume homeostasis, intracellular signal transduction, ion homeostasis, maintenance of permeability of blood-brain barrier, negative regulation of apoptotic process, negative regulation of pancreatic juice secretion, negative regulation of sodium ion transport, osmosensory signaling pathway, peptidyl-threonine phosphorylation, positive regulation of calcium ion transport, positive regulation of ion transmembrane transporter activity, positive regulation of peptidyl-threonine phosphorylation, positive regulation of potassium ion import across plasma membrane, positive regulation of protein localization to plasma membrane, positive regulation of sodium ion transmembrane transporter activity, positive regulation of sodium ion transport, protein autophosphorylation, protein localization to plasma membrane, protein phosphorylation, regulation of calcium ion import, regulation of cation transmembrane transport
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GO - Molecular function (MF):
ATP binding, chloride channel inhibitor activity, potassium channel inhibitor activity, protein kinase activity, protein serine/threonine kinase activity...
ATP binding, chloride channel inhibitor activity, potassium channel inhibitor activity, protein kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, adherens junction, bicellular tight junction, cytoplasm...
cytosol, adherens junction, bicellular tight junction, cytoplasm
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WNK lysine deficient protein kinase 3
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*NOTE: the Kaplan plots were collected from OncoLnc