NUAK2
Entrez ID: 81788
Full name: NUAK family kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: CAMKL: NuaK
Chromosomal location: 1q32.1
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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NUAK2
Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasi...
Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1.
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GO - Biological processes (BP):
actin cytoskeleton organization, apoptotic process, cellular response to glucose starvation, intracellular signal transduction, negative regulation of apoptotic process, protein phosphorylation...
actin cytoskeleton organization, apoptotic process, cellular response to glucose starvation, intracellular signal transduction, negative regulation of apoptotic process, protein phosphorylation
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GO - Molecular function (MF):
ATP binding, magnesium ion binding, protein serine/threonine kinase activity...
ATP binding, magnesium ion binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
nucleus, cytoplasm...
nucleus, cytoplasm
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NUAK family kinase 2
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Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
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Minimum 5 samples
Minimum 10 samples
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Kaplan plot for NUAK2 in
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*NOTE: the Kaplan plots were collected from OncoLnc