TAOK3
Entrez ID: 51347
Full name: TAO kinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE20: TAO
Chromosomal location: 12q24.23
Substructure location: Gatekeeper: 101 A-loop: 164...183 G-loop: [N/A] αC-helix: [N/A]
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TAOK3
Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating ...
Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).
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GO - Biological processes (BP):
activation of MAPKK activity, activation of protein kinase activity, cellular response to DNA damage stimulus, DNA repair, MAPK cascade, mitotic G2 DNA damage checkpoint, negative regulation of JNK cascade, positive regulation of JNK cascade, positive regulation of JUN kinase activity, positive regu...
activation of MAPKK activity, activation of protein kinase activity, cellular response to DNA damage stimulus, DNA repair, MAPK cascade, mitotic G2 DNA damage checkpoint, negative regulation of JNK cascade, positive regulation of JNK cascade, positive regulation of JUN kinase activity, positive regulation of stress-activated MAPK cascade, protein autophosphorylation, protein phosphorylation, regulation of mitotic cell cycle, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade
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GO - Molecular function (MF):
ATP binding, MAP kinase kinase kinase activity, protein kinase inhibitor activity, protein serine/threonine kinase activity, transferase activity...
ATP binding, MAP kinase kinase kinase activity, protein kinase inhibitor activity, protein serine/threonine kinase activity, transferase activity
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GO - Cellular component (CC):
plasma membrane, cytoplasm...
plasma membrane, cytoplasm
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TAO kinase 3
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Kaplan plot for TAOK3 in
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*NOTE: the Kaplan plots were collected from OncoLnc