POMK
Entrez ID: 84197
Full name: protein O-mannose kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: Other-Unique
Chromosomal location: 8p11.21
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
Please click HERE
for better display.
POMK
Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-ace...
Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif.
View more >>
GO - Biological processes (BP):
brain development, carbohydrate phosphorylation, learning or memory, neuromuscular process, neuron migration, protein O-linked glycosylation, sensory perception of pain...
brain development, carbohydrate phosphorylation, learning or memory, neuromuscular process, neuron migration, protein O-linked glycosylation, sensory perception of pain
View more >>
GO - Molecular function (MF):
ATP binding, carbohydrate kinase activity, phosphotransferase activity, alcohol group as acceptor, protein kinase activity...
ATP binding, carbohydrate kinase activity, phosphotransferase activity, alcohol group as acceptor, protein kinase activity
View more >>
GO - Cellular component (CC):
endoplasmic reticulum membrane, integral component of membrane...
endoplasmic reticulum membrane, integral component of membrane
View more >>
protein O-mannose kinase
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for POMK in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc