SGK2
Entrez ID: 10110
Full name: serum/glucocorticoid regulated kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: AGC: SGK
Chromosomal location: 20q13.12
Substructure location: Gatekeeper: 173 A-loop: 236...259 G-loop: [N/A] αC-helix: [N/A]
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SGK2
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na+ channels: SCNN1A/ENAC, K+ channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transpo...
Serine/threonine-protein kinase which is involved in the regulation of a wide variety of ion channels, membrane transporters, cell growth, survival and proliferation. Up-regulates Na+ channels: SCNN1A/ENAC, K+ channels: KCNA3/Kv1.3, KCNE1 and KCNQ1, amino acid transporter: SLC6A19, glutamate transporter: SLC1A6/EAAT4, glutamate receptors: GRIA1/GLUR1 and GRIK2/GLUR6, Na+/H+ exchanger: SLC9A3/NHE3, and the Na+/K+ ATPase.
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GO - Biological processes (BP):
intracellular signal transduction, ion transmembrane transport, peptidyl-serine phosphorylation, positive regulation of transporter activity, protein phosphorylation, regulation of cell growth, regulation of cell population proliferation, response to oxidative stress...
intracellular signal transduction, ion transmembrane transport, peptidyl-serine phosphorylation, positive regulation of transporter activity, protein phosphorylation, regulation of cell growth, regulation of cell population proliferation, response to oxidative stress
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GO - Molecular function (MF):
ATP binding, potassium channel regulator activity, protein serine/threonine kinase activity, sodium channel regulator activity...
ATP binding, potassium channel regulator activity, protein serine/threonine kinase activity, sodium channel regulator activity
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GO - Cellular component (CC):
cytosol, nucleoplasm...
cytosol, nucleoplasm
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serum/glucocorticoid regulated kinase 2
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Kaplan plot for SGK2 in
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*NOTE: the Kaplan plots were collected from OncoLnc