LATS2
Entrez ID: 26524
Full name: large tumor suppressor kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: AGC: NDR: LATS
Chromosomal location: 13q12.11
Substructure location: Gatekeeper: 745 A-loop: 808...820, 868...878 G-loop: [N/A] αC-helix: [N/A]
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LATS2
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulato...
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ.
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GO - Biological processes (BP):
cell division, G1/S transition of mitotic cell cycle, hippo signaling, hormone-mediated signaling pathway, intracellular signal transduction, negative regulation of canonical Wnt signaling pathway, negative regulation of cyclin-dependent protein serine/threonine kinase activity, peptidyl-serine phos...
cell division, G1/S transition of mitotic cell cycle, hippo signaling, hormone-mediated signaling pathway, intracellular signal transduction, negative regulation of canonical Wnt signaling pathway, negative regulation of cyclin-dependent protein serine/threonine kinase activity, peptidyl-serine phosphorylation, positive regulation of apoptotic process, protein phosphorylation, regulation of organ growth
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GO - Molecular function (MF):
ATP binding, metal ion binding, protein serine/threonine kinase activity...
ATP binding, metal ion binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
centriolar satellite, spindle pole, cytosol, nucleus...
centriolar satellite, spindle pole, cytosol, nucleus
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large tumor suppressor kinase 2
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Kaplan plot for LATS2 in
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*NOTE: the Kaplan plots were collected from OncoLnc