IRAK4
Entrez ID: 51135
Full name: interleukin 1 receptor associated kinase 4
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: IRAK
Chromosomal location: 12q12
Substructure location: Gatekeeper: 262 A-loop: 328...340, 342...353 G-loop: 192...198 αC-helix: 226...239
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IRAK4
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form ...
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways (PubMed:17878374). Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections.
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GO - Biological processes (BP):
cytokine production, innate immune response, interleukin-1-mediated signaling pathway, intracellular signal transduction, JNK cascade, MyD88-dependent toll-like receptor signaling pathway, neutrophil mediated immunity, neutrophil migration, positive regulation of I-kappaB kinase/NF-kappaB signaling,...
cytokine production, innate immune response, interleukin-1-mediated signaling pathway, intracellular signal transduction, JNK cascade, MyD88-dependent toll-like receptor signaling pathway, neutrophil mediated immunity, neutrophil migration, positive regulation of I-kappaB kinase/NF-kappaB signaling, positive regulation of smooth muscle cell proliferation, toll-like receptor 9 signaling pathway, toll-like receptor signaling pathway
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GO - Molecular function (MF):
ATP binding, interleukin-1 receptor binding, magnesium ion binding, protein kinase activity, protein serine/threonine kinase activity...
ATP binding, interleukin-1 receptor binding, magnesium ion binding, protein kinase activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, endosome membrane, extracellular space, nucleus, plasma membrane, cytoplasm...
cytosol, endosome membrane, extracellular space, nucleus, plasma membrane, cytoplasm
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interleukin 1 receptor associated kinase 4
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Kaplan plot for IRAK4 in
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*NOTE: the Kaplan plots were collected from OncoLnc