EIF2AK3
Entrez ID: 9451
Full name: eukaryotic translation initiation factor 2 alpha kinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: PEK: PEK
Chromosomal location: 2p11.2
Substructure location: Gatekeeper: [N/A] A-loop: [N/A] G-loop: 600...607 αC-helix: 630...644
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EIF2AK3
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in...
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response (UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1). Involved in control of mitochondrial morphology and function.
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GO - Biological processes (BP):
activation of cysteine-type endopeptidase activity involved in apoptotic process, angiogenesis, bone mineralization, calcium-mediated signaling, cellular response to amino acid starvation, cellular response to cold, cellular response to glucose starvation, chondrocyte development, eiF2alpha phosphor...
activation of cysteine-type endopeptidase activity involved in apoptotic process, angiogenesis, bone mineralization, calcium-mediated signaling, cellular response to amino acid starvation, cellular response to cold, cellular response to glucose starvation, chondrocyte development, eiF2alpha phosphorylation in response to endoplasmic reticulum stress, endocrine pancreas development, endoplasmic reticulum organization, endoplasmic reticulum unfolded protein response, ER overload response, insulin-like growth factor receptor signaling pathway, negative regulation of myelination, negative regulation of translation, negative regulation of translational initiation in response to stress, ossification, peptidyl-serine phosphorylation, PERK-mediated unfolded protein response, positive regulation of gene expression, positive regulation of protein localization to nucleus, positive regulation of transcription by RNA polymerase I, positive regulation of vascular endothelial growth factor production, protein autophosphorylation, protein phosphorylation, regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation, regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway, regulation of translational initiation by eIF2 alpha phosphorylation, response to endoplasmic reticulum stress, response to manganese-induced endoplasmic reticulum stress, skeletal system development
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GO - Molecular function (MF):
ATP binding, enzyme binding, eukaryotic translation initiation factor 2alpha kinase activity, Hsp90 protein binding, identical protein binding, protein kinase activity, protein phosphatase binding, protein serine/threonine kinase activity...
ATP binding, enzyme binding, eukaryotic translation initiation factor 2alpha kinase activity, Hsp90 protein binding, identical protein binding, protein kinase activity, protein phosphatase binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
endoplasmic reticulum, endoplasmic reticulum membrane, integral component of endoplasmic reticulum membrane, cytoplasm, membrane, perinuclear region of cytoplasm...
endoplasmic reticulum, endoplasmic reticulum membrane, integral component of endoplasmic reticulum membrane, cytoplasm, membrane, perinuclear region of cytoplasm
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eukaryotic translation initiation factor 2 alpha kinase 3
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Kaplan plot for EIF2AK3 in
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*NOTE: the Kaplan plots were collected from OncoLnc