BAZ1B
Entrez ID: 9031
Full name: bromodomain adjacent to zinc finger domain 1B
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Atypical: BAZ
Chromosomal location: 7q11.23
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
Please click HERE
for better display.
BAZ1B
Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes bet...
Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication.
View more >>
GO - Biological processes (BP):
cellular response to DNA damage stimulus, chromatin assembly or disassembly, chromatin remodeling, histone phosphorylation, positive regulation of gene expression, epigenetic, regulation of transcription by RNA polymerase II...
cellular response to DNA damage stimulus, chromatin assembly or disassembly, chromatin remodeling, histone phosphorylation, positive regulation of gene expression, epigenetic, regulation of transcription by RNA polymerase II
View more >>
GO - Molecular function (MF):
ATP binding, histone binding, histone kinase activity, non-membrane spanning protein tyrosine kinase activity, protein tyrosine kinase activity, zinc ion binding...
ATP binding, histone binding, histone kinase activity, non-membrane spanning protein tyrosine kinase activity, protein tyrosine kinase activity, zinc ion binding
View more >>
GO - Cellular component (CC):
nuclear body, nucleoplasm, condensed chromosome, pericentric heterochromatin...
nuclear body, nucleoplasm, condensed chromosome, pericentric heterochromatin
View more >>
bromodomain adjacent to zinc finger domain 1B
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for BAZ1B in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc