DAPK2
Entrez ID: 23604
Full name: death associated protein kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: CAMK: DAPK: DAPK
Chromosomal location: 15q22.31
Substructure location: Gatekeeper: 103 A-loop: 170...192 G-loop: 29...35 αC-helix: 68...80
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DAPK2
Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, w...
Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell death signals, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocytic maturation (PubMed:17347302). Regulates granulocytic motility by controlling cell spreading and polarization (PubMed:24163421).
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GO - Biological processes (BP):
anoikis, apoptotic process, intracellular signal transduction, positive regulation of eosinophil chemotaxis, positive regulation of neutrophil chemotaxis, protein autophosphorylation, protein phosphorylation, regulation of apoptotic process, regulation of autophagy, regulation of intrinsic apoptotic...
anoikis, apoptotic process, intracellular signal transduction, positive regulation of eosinophil chemotaxis, positive regulation of neutrophil chemotaxis, protein autophosphorylation, protein phosphorylation, regulation of apoptotic process, regulation of autophagy, regulation of intrinsic apoptotic signaling pathway
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GO - Molecular function (MF):
ATP binding, calmodulin binding, identical protein binding, protein serine/threonine kinase activity...
ATP binding, calmodulin binding, identical protein binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
Golgi apparatus, nucleus, autophagosome lumen, cytoplasm, cytoplasmic vesicle, intracellular membrane-bounded organelle...
Golgi apparatus, nucleus, autophagosome lumen, cytoplasm, cytoplasmic vesicle, intracellular membrane-bounded organelle
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death associated protein kinase 2
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Kaplan plot for DAPK2 in
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*NOTE: the Kaplan plots were collected from OncoLnc