TNIK
Entrez ID: 23043
Full name: TRAF2 and NCK interacting kinase
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE20: MSN
Chromosomal location: 3q26.2-q26.31
Substructure location: Gatekeeper: 105 A-loop: 170...193 G-loop: 32...39 αC-helix: 63...76
Please click HERE
for better display.
TNIK
Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the respon...
Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.
View more >>
GO - Biological processes (BP):
actin cytoskeleton reorganization, activation of JNKK activity, activation of protein kinase activity, cytoskeleton organization, intracellular signal transduction, microvillus assembly, neuron projection morphogenesis, positive regulation of protein phosphorylation, protein autophosphorylation, pro...
actin cytoskeleton reorganization, activation of JNKK activity, activation of protein kinase activity, cytoskeleton organization, intracellular signal transduction, microvillus assembly, neuron projection morphogenesis, positive regulation of protein phosphorylation, protein autophosphorylation, protein localization to plasma membrane, protein phosphorylation, regulation of dendrite morphogenesis, regulation of mitotic cell cycle, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade, Wnt signaling pathway
View more >>
GO - Molecular function (MF):
ATP binding, protein kinase activity, protein serine/threonine kinase activity...
ATP binding, protein kinase activity, protein serine/threonine kinase activity
View more >>
GO - Cellular component (CC):
cytoskeleton, cytosol, recycling endosome, extracellular exosome, nucleoplasm, nucleus, apical plasma membrane, cytoplasm, glutamatergic synapse, postsynaptic density, intracellular component, presynapse...
cytoskeleton, cytosol, recycling endosome, extracellular exosome, nucleoplasm, nucleus, apical plasma membrane, cytoplasm, glutamatergic synapse, postsynaptic density, intracellular component, presynapse
View more >>
TRAF2 and NCK interacting kinase
Control panel
Show dataset:
Show substructure:
All sites
Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for TNIK in
Download patient group data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc