WNK2
Entrez ID: 65268
Full name: WNK lysine deficient protein kinase 2
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Other: WNK
Chromosomal location: 9q22.31
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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WNK2
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2,...
Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SLC12A2, SCNN1A, SCNN1B, SCNN1D and SGK1 and inhibits SLC12A5. Negatively regulates the EGF-induced activation of the ERK/MAPK-pathway and the downstream cell cycle progression. Affects MAPK3/MAPK1 activity by modulating the activity of MAP2K1 and this modulation depends on phosphorylation of MAP2K1 by PAK1. WNK2 acts by interfering with the activity of PAK1 by controlling the balance of the activity of upstream regulators of PAK1 activity, RHOA and RAC1, which display reciprocal activity.
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GO - Biological processes (BP):
intracellular signal transduction, ion homeostasis, negative regulation of cell population proliferation, negative regulation of ERK1 and ERK2 cascade, negative regulation of sodium ion transport, positive regulation of canonical Wnt signaling pathway, positive regulation of ion transmembrane transp...
intracellular signal transduction, ion homeostasis, negative regulation of cell population proliferation, negative regulation of ERK1 and ERK2 cascade, negative regulation of sodium ion transport, positive regulation of canonical Wnt signaling pathway, positive regulation of ion transmembrane transporter activity, positive regulation of potassium ion import across plasma membrane, positive regulation of sodium ion transmembrane transporter activity, protein autophosphorylation, protein phosphorylation
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GO - Molecular function (MF):
ATP binding, chloride channel inhibitor activity, potassium channel inhibitor activity, protein serine/threonine kinase activity...
ATP binding, chloride channel inhibitor activity, potassium channel inhibitor activity, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytosol, plasma membrane, cytoplasm...
cytosol, plasma membrane, cytoplasm
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WNK lysine deficient protein kinase 2
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Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
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Minimum 10 samples
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Kaplan plot for WNK2 in
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*NOTE: the Kaplan plots were collected from OncoLnc