TRRAP
Entrez ID: 8295
Full name: transformation/transcription domain associated protein
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: Atypical: PIKK: TRRAP
Chromosomal location: 7q22.1
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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TRRAP
Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal h...
Adapter protein, which is found in various multiprotein chromatin complexes with histone acetyltransferase activity (HAT), which gives a specific tag for epigenetic transcription activation. Component of the NuA4 histone acetyltransferase complex which is responsible for acetylation of nucleosomal histones H4 and H2A. Plays a central role in MYC transcription activation, and also participates in cell transformation by MYC. Required for p53/TP53-, E2F1- and E2F4-mediated transcription activation. Also involved in transcription activation mediated by the adenovirus E1A, a viral oncoprotein that deregulates transcription of key genes. Probably acts by linking transcription factors such as E1A, MYC or E2F1 to HAT complexes such as STAGA thereby allowing transcription activation. Probably not required in the steps following histone acetylation in processes of transcription activation. May be required for the mitotic checkpoint and normal cell cycle progression. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome.
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GO - Biological processes (BP):
beta-catenin-TCF complex assembly, DNA repair, histone acetylation, histone deubiquitination, histone H2A acetylation, histone H4 acetylation, protein deubiquitination, regulation of transcription, DNA-templated...
beta-catenin-TCF complex assembly, DNA repair, histone acetylation, histone deubiquitination, histone H2A acetylation, histone H4 acetylation, protein deubiquitination, regulation of transcription, DNA-templated
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GO - Molecular function (MF):
transcription coregulator activity...
transcription coregulator activity
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GO - Cellular component (CC):
Golgi apparatus, NuA4 histone acetyltransferase complex, nucleoplasm, nucleus, PCAF complex, SAGA complex, STAGA complex, Swr1 complex, transcription factor TFTC complex...
Golgi apparatus, NuA4 histone acetyltransferase complex, nucleoplasm, nucleus, PCAF complex, SAGA complex, STAGA complex, Swr1 complex, transcription factor TFTC complex
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transformation/transcription domain associated protein
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Gatekeeper
A-loop
G-loop
αC-helix
Gatekeeper
A-loop
G-loop
αC-helix
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Minimum 10 samples
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Kaplan plot for TRRAP in
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*NOTE: the Kaplan plots were collected from OncoLnc