RIPK3
Entrez ID: 11035
Full name: receptor interacting serine/threonine kinase 3
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: TKL: RIPK
Chromosomal location: 14q12
Substructure location: Gatekeeper: 94 A-loop: [N/A] G-loop: [N/A] αC-helix: [N/A]
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RIPK3
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzy...
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
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GO - Biological processes (BP):
activation of protein kinase activity, amyloid fibril formation, apoptotic signaling pathway, cellular protein modification process, cellular response to hydrogen peroxide, I-kappaB kinase/NF-kappaB signaling, lymph node development, necroptotic process, positive regulation of intrinsic apoptotic si...
activation of protein kinase activity, amyloid fibril formation, apoptotic signaling pathway, cellular protein modification process, cellular response to hydrogen peroxide, I-kappaB kinase/NF-kappaB signaling, lymph node development, necroptotic process, positive regulation of intrinsic apoptotic signaling pathway, positive regulation of ligase activity, positive regulation of necroptotic process, positive regulation of NF-kappaB transcription factor activity, positive regulation of oxidoreductase activity, positive regulation of phosphatase activity, positive regulation of reactive oxygen species metabolic process, programmed necrotic cell death, protein autophosphorylation, regulation of activated T cell proliferation, regulation of activation-induced cell death of T cells, regulation of adaptive immune response, regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation, regulation of interferon-gamma production, regulation of T cell mediated cytotoxicity, signal transduction, spleen development, T cell differentiation in thymus, T cell homeostasis, thymus development
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GO - Molecular function (MF):
ATP binding, identical protein binding, NF-kappaB-inducing kinase activity, protein-containing complex binding, protein kinase activity, protein serine/threonine kinase activity, transcription coactivator activity...
ATP binding, identical protein binding, NF-kappaB-inducing kinase activity, protein-containing complex binding, protein kinase activity, protein serine/threonine kinase activity, transcription coactivator activity
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GO - Cellular component (CC):
cytosol, mitochondrion, plasma membrane, protein-containing complex...
cytosol, mitochondrion, plasma membrane, protein-containing complex
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receptor interacting serine/threonine kinase 3
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Kaplan plot for RIPK3 in
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*NOTE: the Kaplan plots were collected from OncoLnc