MAP3K4
Entrez ID: 4216
Full name: mitogen-activated protein kinase kinase kinase 4
External links: HGNC UniprotKB Ensembl RefSeq COSMIC
Family: STE: STE11: MEKK4
Chromosomal location: 6q26
Substructure location: Gatekeeper: A-loop: G-loop: αC-helix:
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MAP3K4
Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6....
Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.
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GO - Biological processes (BP):
activation of MAPKK activity, activation of protein kinase activity, chorionic trophoblast cell differentiation, intracellular signal transduction, male germ-line sex determination, placenta development, positive regulation of JUN kinase activity, positive regulation of p38MAPK cascade, positive reg...
activation of MAPKK activity, activation of protein kinase activity, chorionic trophoblast cell differentiation, intracellular signal transduction, male germ-line sex determination, placenta development, positive regulation of JUN kinase activity, positive regulation of p38MAPK cascade, positive regulation of telomerase activity, positive regulation of telomere capping, positive regulation of telomere maintenance via telomerase, regulation of gene expression, regulation of mitotic cell cycle, response to UV-C, signal transduction by protein phosphorylation, stress-activated protein kinase signaling cascade
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GO - Molecular function (MF):
ATP binding, MAP kinase kinase kinase activity, metal ion binding, protein serine/threonine kinase activity...
ATP binding, MAP kinase kinase kinase activity, metal ion binding, protein serine/threonine kinase activity
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GO - Cellular component (CC):
cytoplasm, perinuclear region of cytoplasm...
cytoplasm, perinuclear region of cytoplasm
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mitogen-activated protein kinase kinase kinase 4
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*NOTE: the Kaplan plots were collected from OncoLnc