| Tag | Content |
|---|---|
| Uniprot ID | A0A0G2JTA6 |
| Entrez ID | 24483 |
| Genbank protein ID | EDM12157.1 |
| Genbank nucleotide ID | NM_031511.2 |
| Ensembl protein ID | ENSRNOP00000068633 |
| Ensembl nucleotide ID | ENSRNOG00000020369 |
| Gene name | Insulin-like growth factor 2, isoform CRA_b |
| Gene symbol | Igf2 |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MGGSVAGFQV PMGIPVGKSM LVLLISLAFA LCCIAAYRPS ETLCGGELVD TLQFVCSDRG 60 FYFSRPSSRA NRRSRGIVEE CCFRSCDLAL LETYCATPAK SERDVSTSQA VLPDDFPRYP 120 VGKFFKFDTW RQSAGRLRRG LPALLRARRG RMLAKELEAF REAKRHRPLI VLPPKDPAHG 180 GASSEMSSNH Q 191 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | IGF2 | 281240 | P07456 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | IGF2 | 100861277 | Q153G7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | IGF2 | 3481 | P01344 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Igf2 | 16002 | P09535 | CPO | E14.5, E18.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | Igf2 | 24483 | A0A0G2JTA6 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005615 | extracellular space |
| GO:0016021 | integral component of membrane |
| GO:0008083 | growth factor activity |
| GO:0005179 | hormone activity |
| GO:0005158 | insulin receptor binding |
| GO:0005159 | insulin-like growth factor receptor binding |
| GO:0005178 | integrin binding |
| GO:0043539 | protein serine/threonine kinase activator activity |
| GO:0009887 | animal organ morphogenesis |
| GO:0060669 | embryonic placenta morphogenesis |
| GO:0031017 | exocrine pancreas development |
| GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0001649 | osteoblast differentiation |
| GO:0042104 | positive regulation of activated T cell proliferation |
| GO:2000467 | positive regulation of glycogen (starch) synthase activity |
| GO:0045725 | positive regulation of glycogen biosynthetic process |
| GO:0046628 | positive regulation of insulin receptor signaling pathway |
| GO:0043410 | positive regulation of MAPK cascade |
| GO:0045840 | positive regulation of mitotic nuclear division |
| GO:0040018 | positive regulation of multicellular organism growth |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation |
| GO:0051897 | positive regulation of protein kinase B signaling |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0031056 | regulation of histone modification |
| GO:0051147 | regulation of muscle cell differentiation |
| GO:0060720 | spongiotrophoblast cell proliferation |
| GO:0051146 | striated muscle cell differentiation |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00262 | INSULIN |