| Tag | Content |
|---|---|
| Uniprot ID | P07456; A0A5F2; Q2HJN0; |
| Entrez ID | 281240 |
| Genbank protein ID | CAA37620.1; ABD34310.1; CAA37861.1; AAI16040.1; |
| Genbank nucleotide ID | XM_005227274.3; XM_005227273.1; XM_005227275.3; XM_005227276.1; XM_015461332.1; NM_174087.3; |
| Ensembl protein ID | ENSBTAP00000017372; ENSBTAP00000073154; |
| Ensembl nucleotide ID | ENSBTAG00000013066 |
| Gene name | Insulin-like growth factor II |
| Gene symbol | IGF2 |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is required for IGF2 signaling. |
| Sequence | MGITAGKSVL VLLAFLAFAS CCYAAYRPSE TLCGGELVDT LQFVCGDRGF YFSRPSSRIN 60 RRSRGIVEEC CFRSCDLALL ETYCATPAKS ERDVSASTTV LPDDVTAYPV GKFFQYDIWK 120 QSTQRLRRGL PAFLRARRGR TLAKELEALR EAKSHRPLIA LPTQDPATHG GASSKASSD 179 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | IGF2 | 281240 | P07456 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | IGF2 | 100861277 | Q153G7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | IGF2 | 3481 | P01344 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Igf2 | 16002 | P09535 | CPO | E14.5, E18.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | Igf2 | 24483 | A0A0G2JTA6 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005615 | extracellular space |
| GO:0008083 | growth factor activity |
| GO:0005179 | hormone activity |
| GO:0005178 | integrin binding |
| GO:0001892 | embryonic placenta development |
| GO:0060669 | embryonic placenta morphogenesis |
| GO:0006006 | glucose metabolic process |
| GO:0001701 | in utero embryonic development |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0001503 | ossification |
| GO:0051781 | positive regulation of cell division |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0031056 | regulation of histone modification |
| GO:0051147 | regulation of muscle cell differentiation |
| GO:0032868 | response to insulin |
| Keyword ID | Keyword Term |
|---|---|
| KW-0119 | Carbohydrate metabolism |
| KW-0165 | Cleavage on pair of basic residues |
| KW-0903 | Direct protein sequencing |
| KW-1015 | Disulfide bond |
| KW-0313 | Glucose metabolism |
| KW-0325 | Glycoprotein |
| KW-0339 | Growth factor |
| KW-0372 | Hormone |
| KW-0497 | Mitogen |
| KW-0892 | Osteogenesis |
| KW-1185 | Reference proteome |
| KW-0964 | Secreted |
| KW-0732 | Signal |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00262 | INSULIN |