| Tag | Content |
|---|---|
| Uniprot ID | P09535; E9QLW5; |
| Entrez ID | 16002 |
| Genbank protein ID | AAC53516.1; CAA50737.1; CAA50738.1; AAH53489.1; AAA37923.1; AAA37683.1; AAA37926.1; |
| Genbank nucleotide ID | NM_001315488.1; NM_001315489.1; XM_006508487.1; NM_001122737.2; NM_010514.3; NM_001122736.2; |
| Ensembl protein ID | ENSMUSP00000101556; ENSMUSP00000095549; ENSMUSP00000114076; ENSMUSP00000101555; ENSMUSP00000000033; |
| Ensembl nucleotide ID | ENSMUSG00000048583 |
| Gene name | Insulin-like growth factor II |
| Gene symbol | Igf2 |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | E14.5, E18.5 |
| Data sources | Manually collected |
| Reference | 27933520; 9291469; |
| Functional description | The insulin-like growth factors possess growth-promoting activity (Probable). Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development (Probable) (PubMed:2330056, PubMed:12087403). IGF-II is influenced by placental lactogen (Probable). Also involved in tissue differentiation (Probable). Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (PubMed:16901893). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (By similarity). |
| Sequence | MGIPVGKSML VLLISLAFAL CCIAAYGPGE TLCGGELVDT LQFVCSDRGF YFSRPSSRAN 60 RRSRGIVEEC CFRSCDLALL ETYCATPAKS ERDVSTSQAV LPDDFPRYPV GKFFQYDTWR 120 QSAGRLRRGL PALLRARRGR MLAKELKEFR EAKRHRPLIV LPPKDPAHGG ASSEMSSNHQ 180 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | IGF2 | 281240 | P07456 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | IGF2 | 100861277 | Q153G7 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | IGF2 | 3481 | P01344 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Igf2 | 16002 | P09535 | CPO | E14.5, E18.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | Igf2 | 24483 | A0A0G2JTA6 | Rattus norvegicus | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005158 | insulin receptor binding | ISO |
| GO:0005159 | insulin-like growth factor receptor binding | ISO |
| GO:0005159 | insulin-like growth factor receptor binding | IPI |
| GO:0005178 | integrin binding | ISS |
| GO:0005178 | integrin binding | ISO |
| GO:0005179 | hormone activity | IEA |
| GO:0005515 | protein binding | IPI |
| GO:0008083 | growth factor activity | ISO |
| GO:0043539 | protein serine/threonine kinase activator activity | IMP |
| GO:0048018 | receptor ligand activity | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP |
| GO:0001649 | osteoblast differentiation | IEP |
| GO:0001701 | in utero embryonic development | IMP |
| GO:0001892 | embryonic placenta development | IMP |
| GO:0001934 | positive regulation of protein phosphorylation | IMP |
| GO:0006006 | glucose metabolic process | IEA |
| GO:0007613 | memory | ISO |
| GO:0008284 | positive regulation of cell population proliferation | ISS |
| GO:0008284 | positive regulation of cell population proliferation | ISO |
| GO:0009887 | animal organ morphogenesis | IMP |
| GO:0014070 | response to organic cyclic compound | ISO |
| GO:0031017 | exocrine pancreas development | IMP |
| GO:0031056 | regulation of histone modification | IMP |
| GO:0035094 | response to nicotine | ISO |
| GO:0038028 | insulin receptor signaling pathway via phosphatidylinositol 3-kinase | IMP |
| GO:0040018 | positive regulation of multicellular organism growth | IMP |
| GO:0042104 | positive regulation of activated T cell proliferation | ISO |
| GO:0042493 | response to drug | ISO |
| GO:0043085 | positive regulation of catalytic activity | IMP |
| GO:0043410 | positive regulation of MAPK cascade | ISO |
| GO:0043536 | positive regulation of blood vessel endothelial cell migration | ISO |
| GO:0045725 | positive regulation of glycogen biosynthetic process | IMP |
| GO:0045766 | positive regulation of angiogenesis | ISO |
| GO:0045840 | positive regulation of mitotic nuclear division | ISO |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | IGI |
| GO:0045953 | negative regulation of natural killer cell mediated cytotoxicity | ISO |
| GO:0046628 | positive regulation of insulin receptor signaling pathway | ISO |
| GO:0046628 | positive regulation of insulin receptor signaling pathway | IMP |
| GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | IMP |
| GO:0051146 | striated muscle cell differentiation | IGI |
| GO:0051147 | regulation of muscle cell differentiation | IMP |
| GO:0051781 | positive regulation of cell division | IEA |
| GO:0051897 | positive regulation of protein kinase B signaling | ISO |
| GO:0060669 | embryonic placenta morphogenesis | IMP |
| GO:0060720 | spongiotrophoblast cell proliferation | IMP |
| GO:0071902 | positive regulation of protein serine/threonine kinase activity | IEA |
| GO:0090031 | positive regulation of steroid hormone biosynthetic process | ISO |
| GO:1905564 | positive regulation of vascular endothelial cell proliferation | ISO |
| GO:2000467 | positive regulation of glycogen (starch) synthase activity | IMP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005615 | extracellular space | ISO |
| GO:0005615 | extracellular space | IDA |
| GO:0062023 | collagen-containing extracellular matrix | HDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-109582 | Hemostasis | IEA |
| R-MMU-114608 | Platelet degranulation | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) | IEA |
| R-MMU-2428924 | IGF1R signaling cascade | IEA |
| R-MMU-2428928 | IRS-related events triggered by IGF1R | IEA |
| R-MMU-2428933 | SHC-related events triggered by IGF1R | IEA |
| R-MMU-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | IEA |
| R-MMU-392499 | Metabolism of proteins | IEA |
| R-MMU-76002 | Platelet activation, signaling and aggregation | IEA |
| R-MMU-76005 | Response to elevated platelet cytosolic Ca2+ | IEA |
| R-MMU-9006934 | Signaling by Receptor Tyrosine Kinases | IEA |
| Keyword ID | Keyword Term |
|---|---|
| KW-0877 | Alternative promoter usage |
| KW-0119 | Carbohydrate metabolism |
| KW-0165 | Cleavage on pair of basic residues |
| KW-0903 | Direct protein sequencing |
| KW-1015 | Disulfide bond |
| KW-0313 | Glucose metabolism |
| KW-0339 | Growth factor |
| KW-0372 | Hormone |
| KW-0497 | Mitogen |
| KW-0892 | Osteogenesis |
| KW-1185 | Reference proteome |
| KW-0964 | Secreted |
| KW-0732 | Signal |
| PROSITE ID | PROSITE Term |
|---|---|
| PS00262 | INSULIN |