| Tag | Content |
|---|---|
| Uniprot ID | A0A0G2JVZ6 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSRNOP00000069681 |
| Ensembl nucleotide ID | ENSRNOG00000004912 |
| Gene name | Integrin subunit alpha V |
| Gene symbol | Itgav |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MADPGRLLLR PRPGGLLLLL LGLLLPFAGS FNLDVESPAE YAGPEGSYFG FAVDFFVPST 60 SSRMFLLVGA PKANTTQPGI IEGGQVLKCD CSSSRRCQPI EFDSTGNRDY AKDDPLEFKS 120 HQWFGASVRS KQDKILACAP LYHWRTEMKQ EREPVGTCFL QDGTKTVEYA PCRSKNIDAD 180 GQGFCQGGFS IDFTKADRVL LGGPGSFYWQ GQLISDQVAE IISKYDPNVY SIKYNNQLAT 240 RTAQAIFDDS YLGYSVAVGD FNGDGIEDFV SGVPRAARTL GMVYIYDGKN MSSLHNFTGE 300 QMAAYFGFSV AATDINGDDY ADVFIGAPLF MDRGSDGKLQ EVGQVSVSLQ RASGDFQTTK 360 LNGFEVFARF GSAIAPLGDL DQDGFNDIAI AAPYGGEDKK GLVYIFNGRS TGLNSVPSQI 420 LQGQWAAQSM PPSFGYSMKG ATDVDRNGYP DLVVGAFGVD RAVLYRIRAR PVVTVNAGLE 480 VYPSILNQDN KICPLPGTAL KVSCSNTEFT ESADGKGTLP RKLRYFQVEL LLDKLKQKGA 540 IRRALFLHNR SPGHSKDMTV FRGGQTQCEE LVAYLRCQSQ SQKILRPSTQ DKERLVGYRV 600 VSTSKGLVSV EQRAAAAGKS AVWAHILLDC GEDNVCKPKL EVSVDSDQKK IYIGDDNPLT 660 LTVKAQNQGE GAYEAELIVS IPPQADFIGV VRNNEALARL SCAFKTENQT RQVVCDLGNP 720 MKAGTQLLAG LRFSVHQQSE MDTSVKFDLK IQSSNSFDNV SPVVSYKVDL AVLAAVEIRG 780 VSSPDHIFLP IPNWEYKETP ETEEDVGPVV QHIYELRNNG PSSFSKAILN LQWPYKYNNN 840 TLLYILHYDI DGPMNCTADT EINPLRIKSM SLQTPEKNDT AAEQGGRNHL ITKRDLSLSE 900 GDVHTLGCGT AQCLQITCQV GRLDRGKSAI LYVKSLLWTE TFMNKENQNH SYSLKSSASF 960 NIIEFPYKNL PIEDLFNSTL VTTNITWGIQ PAPMPVPVWV IILAVLAGLL LLAVLVFVMY 1020 RMGFFKRVRP PQEEQEREQL QPHENGEGNS ET 1052 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ITGAV | 281875 | A0A3Q1MXS2 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | ITGAV | A0A452E162 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | ITGAV | 3685 | P06756 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Itgav | 16410 | P43406 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ITGAV | A0A2I3SM65 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | ITGAV | F1RYJ4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | ITGAV | 100008956 | A0A5F9D0E2 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Itgav | A0A0G2JVZ6 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | itgav | B8JLK8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0035868 | alphav-beta3 integrin-HMGB1 complex |
| GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex |
| GO:0005623 | cell |
| GO:0009986 | cell surface |
| GO:0005829 | cytosol |
| GO:0009897 | external side of plasma membrane |
| GO:0031527 | filopodium membrane |
| GO:0005925 | focal adhesion |
| GO:0034683 | integrin alphav-beta3 complex |
| GO:0034684 | integrin alphav-beta5 complex |
| GO:0034685 | integrin alphav-beta6 complex |
| GO:0034686 | integrin alphav-beta8 complex |
| GO:0008305 | integrin complex |
| GO:0031258 | lamellipodium membrane |
| GO:0016020 | membrane |
| GO:0031528 | microvillus membrane |
| GO:0005886 | plasma membrane |
| GO:0032587 | ruffle membrane |
| GO:0019960 | C-X3-C chemokine binding |
| GO:0050840 | extracellular matrix binding |
| GO:1990430 | extracellular matrix protein binding |
| GO:0017134 | fibroblast growth factor binding |
| GO:0001968 | fibronectin binding |
| GO:0031994 | insulin-like growth factor I binding |
| GO:0005178 | integrin binding |
| GO:0038132 | neuregulin binding |
| GO:0001846 | opsonin binding |
| GO:0002020 | protease binding |
| GO:0005080 | protein kinase C binding |
| GO:0005102 | signaling receptor binding |
| GO:0005245 | voltage-gated calcium channel activity |
| GO:0001525 | angiogenesis |
| GO:0038027 | apolipoprotein A-I-mediated signaling pathway |
| GO:0043277 | apoptotic cell clearance |
| GO:0001568 | blood vessel development |
| GO:0070588 | calcium ion transmembrane transport |
| GO:0007155 | cell adhesion |
| GO:0033627 | cell adhesion mediated by integrin |
| GO:0016477 | cell migration |
| GO:0007160 | cell-matrix adhesion |
| GO:0031589 | cell-substrate adhesion |
| GO:0035987 | endodermal cell differentiation |
| GO:0070371 | ERK1 and ERK2 cascade |
| GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand |
| GO:0034113 | heterotypic cell-cell adhesion |
| GO:0007229 | integrin-mediated signaling pathway |
| GO:0050919 | negative chemotaxis |
| GO:2000536 | negative regulation of entry of bacterium into host cell |
| GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| GO:0010888 | negative regulation of lipid storage |
| GO:0032369 | negative regulation of lipid transport |
| GO:0050748 | negative regulation of lipoprotein metabolic process |
| GO:0045715 | negative regulation of low-density lipoprotein particle receptor biosynthetic process |
| GO:0010745 | negative regulation of macrophage derived foam cell differentiation |
| GO:0045785 | positive regulation of cell adhesion |
| GO:0030335 | positive regulation of cell migration |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0007204 | positive regulation of cytosolic calcium ion concentration |
| GO:0033690 | positive regulation of osteoblast proliferation |
| GO:0050764 | regulation of phagocytosis |
| GO:1901388 | regulation of transforming growth factor beta activation |
| GO:0034446 | substrate adhesion-dependent cell spreading |
| GO:0038044 | transforming growth factor-beta secretion |
| GO:0001570 | vasculogenesis |
| GO:0046718 | viral entry into host cell |