| Tag | Content |
|---|---|
| Uniprot ID | A0A452E162 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSCHIP00000005743 |
| Ensembl nucleotide ID | ENSCHIG00000009619 |
| Gene name | Integrin_alpha2 domain-containing protein |
| Gene symbol | ITGAV |
| Organism | Capra hircus |
| NCBI taxa ID | 9925 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MASLPRLRLR LRPRRLLLLL PGILLPLCGA FNLDVESPAE YSGPEGSYFG FAVDFFVPSV 60 SSRMFLLVGA PKANTTQPGI VEGGQVLKCD WSSHRRCQPI EFDATGNRDY AKDDPLEFKS 120 HQWFGASVRS KQDKILACAP LYHWRTEMKQ EREPVGTCFL QDGTKTVEYA PCRSKNIDAD 180 GQGFCQGGFS IDFTKADRVL LGGPGSFYWQ GQLISDQVAE IVSKYDPKVY SIKYNNQLAT 240 RTAQAIFDDS YLGYSVAVGD FNGDGIDDFV SGVPRAARTL GMVYIYDGKN MSSLHNFTGE 300 QMAAYFGFSV AATDINGDDY ADVFIGAPLF MDRGSDGKLQ EVGQVSVALQ KASGDFQTIK 360 LNGFEVFARF GSAIAPLGDL DQDGFNDIAI AAPYGGEDKK GIVYIFNGRP TGLNAVPSQI 420 LEGKWAARSM PPSFGYSMKG ATDIDKNGYP DLIVGAFGVD RAVLYRARPV ITVNAGLEVY 480 PSILNQENKT CPLPGTDLKV SCFNVRFCLK ADGKGALPTK LDFQVELLLD KLKQKGAIRR 540 ALFLHNRSPG HSKNMTISRG GQMQCEELIA YLRDESEFRD KLTPITIFME YWLDYRTAAD 600 ATGLQPILNQ FTPANVSRQA HILLDCGEDN VCKPKLEVSV DSDQKKIYIG DDNPLTLIVK 660 AQNQGEGAYE AELIVSIPLQ ADFIGVVRNS EALARLSCAF KTENQTRQVV CDLGNPMKAG 720 TQLLAGLRFS VHQQSEMDTS VKFDLQIQSS NLFDKVSPVV SYKVDLAVLA AVEIRGVSSP 780 DHIFLPIPNW KYKENPETEE DVGPVVQHIY ELRNNGPSSF SKAMLHLQWP YKYNNNTLLY 840 ILQYDIDGPM NCTSDMEINP LRIKISNSQT SEKNDTIGGQ GDRNHLITKR DLTLSEGDVH 900 TLGCGIAECL KIVCQVGRLD RGKSAILYVR SLLWTETFMN KENQNHSYSL KSSASFNVIE 960 FPYKNLPIED IFNSTLVTTN VTWGIQPAPM PVPVWVIILA VLAGLLLLAV LVFVMYRMGF 1020 FKRVRPPQEE QEREQLQPHE NGEGNSET 1048 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | ITGAV | 281875 | A0A3Q1MXS2 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | ITGAV | A0A452E162 | Capra hircus | Prediction | More>> | |||
| 1:1 ortholog | ITGAV | 3685 | P06756 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Itgav | 16410 | P43406 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | ITGAV | A0A2I3SM65 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | ITGAV | F1RYJ4 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | ITGAV | 100008956 | A0A5F9D0E2 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Itgav | A0A0G2JVZ6 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | itgav | B8JLK8 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0035868 | alphav-beta3 integrin-HMGB1 complex |
| GO:0035867 | alphav-beta3 integrin-IGF-1-IGF1R complex |
| GO:0005829 | cytosol |
| GO:0009897 | external side of plasma membrane |
| GO:0031527 | filopodium membrane |
| GO:0005925 | focal adhesion |
| GO:0034683 | integrin alphav-beta3 complex |
| GO:0034684 | integrin alphav-beta5 complex |
| GO:0034685 | integrin alphav-beta6 complex |
| GO:0034686 | integrin alphav-beta8 complex |
| GO:0031258 | lamellipodium membrane |
| GO:0031528 | microvillus membrane |
| GO:0032587 | ruffle membrane |
| GO:0019960 | C-X3-C chemokine binding |
| GO:0050840 | extracellular matrix binding |
| GO:1990430 | extracellular matrix protein binding |
| GO:0017134 | fibroblast growth factor binding |
| GO:0001968 | fibronectin binding |
| GO:0031994 | insulin-like growth factor I binding |
| GO:0005178 | integrin binding |
| GO:0038132 | neuregulin binding |
| GO:0001846 | opsonin binding |
| GO:0002020 | protease binding |
| GO:0005080 | protein kinase C binding |
| GO:0005245 | voltage-gated calcium channel activity |
| GO:0001525 | angiogenesis |
| GO:0038027 | apolipoprotein A-I-mediated signaling pathway |
| GO:0043277 | apoptotic cell clearance |
| GO:0033627 | cell adhesion mediated by integrin |
| GO:0007160 | cell-matrix adhesion |
| GO:0035987 | endodermal cell differentiation |
| GO:0070371 | ERK1 and ERK2 cascade |
| GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand |
| GO:0034113 | heterotypic cell-cell adhesion |
| GO:0007229 | integrin-mediated signaling pathway |
| GO:0050919 | negative chemotaxis |
| GO:2000536 | negative regulation of entry of bacterium into host cell |
| GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| GO:0010888 | negative regulation of lipid storage |
| GO:0032369 | negative regulation of lipid transport |
| GO:0050748 | negative regulation of lipoprotein metabolic process |
| GO:0045715 | negative regulation of low-density lipoprotein particle receptor biosynthetic process |
| GO:0010745 | negative regulation of macrophage derived foam cell differentiation |
| GO:0045785 | positive regulation of cell adhesion |
| GO:0030335 | positive regulation of cell migration |
| GO:0033690 | positive regulation of osteoblast proliferation |
| GO:0050764 | regulation of phagocytosis |
| GO:1901388 | regulation of transforming growth factor beta activation |
| GO:0034446 | substrate adhesion-dependent cell spreading |
| GO:0038044 | transforming growth factor-beta secretion |
| GO:0046718 | viral entry into host cell |