| Tag | Content |
|---|---|
| Uniprot ID | A0A0G2JW78 |
| Entrez ID | 24705 |
| Genbank protein ID | EDM05963.1 |
| Genbank nucleotide ID | XM_017597008.1; XM_017597009.1; XM_017597011.1; XM_008767945.2; XM_017597010.1; |
| Ensembl protein ID | ENSRNOP00000069776 |
| Ensembl nucleotide ID | ENSRNOG00000009972 |
| Gene name | Retinoic acid receptor, alpha |
| Gene symbol | Rara |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MASNSSSCPT PGGGHLNGYP VPPYAFFFPP MLGGLSPPGA LTSLQHQLPV SGYSTPSPAT 60 IETQSSSSEE IVPSPPSPPP LPRIYKPCFV CQDKSSGYHY GVSACEGCKG FFRRSIQKNM 120 VYTCHRDKNC IINKVTRNRC QYCRLQKCFE VGMSKESVRN DRNKKKKETP KPECSESYTL 180 TPEVGELIEK VRKAHQETFP ALCQLGKYTT NNSSEQRVSL DIDLWDKFSE LSTKCIIKTV 240 EFAKQLPGFT TLTIADQITL LKAACLDILI LRICTRYTPE QDTMTFSDGL TLNRTQMHNA 300 GFGPLTDLVF AFANQLLPLE MDDAETGLLS AICLICGDRQ DLEQPDKVDM LQEPLLEALK 360 VYVRKRRPSR PHMFPKMLMK ITDLRSISAK GAERVITLKM EIPGSMPPLI QEMLENSEGL 420 DTLSGQSGGG TRDGGGLAPP PGSCSPSLSP SSHRSSPATQ SP 462 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | RARA | 534280 | F1MWQ3 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | RARA | 102188350 | A0A452EMU9 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | RARA | 5914 | P10276 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Rara | 19401 | P11416 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | RARA | 454647 | A0A2J8KGL7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | RARA | 396709 | A0A480PNE7 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | RARA | G1TI43 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Rara | 24705 | A0A0G2JW78 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | raraa | 30680 | T2DKU4 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0015629 | actin cytoskeleton |
| GO:0005737 | cytoplasm |
| GO:0005829 | cytosol |
| GO:0030425 | dendrite |
| GO:0042025 | host cell nucleus |
| GO:0043005 | neuron projection |
| GO:0043025 | neuronal cell body |
| GO:0000790 | nuclear chromatin |
| GO:0005654 | nucleoplasm |
| GO:0005634 | nucleus |
| GO:0048471 | perinuclear region of cytoplasm |
| GO:0090575 | RNA polymerase II transcription factor complex |
| GO:0051393 | alpha-actinin binding |
| GO:0031490 | chromatin DNA binding |
| GO:0003677 | DNA binding |
| GO:0003700 | DNA-binding transcription factor activity |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| GO:0008144 | drug binding |
| GO:0019899 | enzyme binding |
| GO:0042826 | histone deacetylase binding |
| GO:0098531 | ligand-activated transcription factor activity |
| GO:0048027 | mRNA 5'-UTR binding |
| GO:0004879 | nuclear receptor activity |
| GO:0030374 | nuclear receptor transcription coactivator activity |
| GO:0019904 | protein domain specific binding |
| GO:0051018 | protein kinase A binding |
| GO:0043422 | protein kinase B binding |
| GO:0001972 | retinoic acid binding |
| GO:0044323 | retinoic acid-responsive element binding |
| GO:0001012 | RNA polymerase II regulatory region DNA binding |
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| GO:0043565 | sequence-specific DNA binding |
| GO:0038023 | signaling receptor activity |
| GO:0005102 | signaling receptor binding |
| GO:0003707 | steroid hormone receptor activity |
| GO:0003713 | transcription coactivator activity |
| GO:0003714 | transcription corepressor activity |
| GO:0008134 | transcription factor binding |
| GO:0044212 | transcription regulatory region DNA binding |
| GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| GO:0000900 | translation repressor activity, mRNA regulatory element binding |
| GO:0008270 | zinc ion binding |
| GO:0043277 | apoptotic cell clearance |
| GO:0060348 | bone development |
| GO:0060349 | bone morphogenesis |
| GO:0030154 | cell differentiation |
| GO:0071391 | cellular response to estrogen stimulus |
| GO:0071222 | cellular response to lipopolysaccharide |
| GO:0071300 | cellular response to retinoic acid |
| GO:0060591 | chondroblast differentiation |
| GO:0031076 | embryonic camera-type eye development |
| GO:0048568 | embryonic organ development |
| GO:0060429 | epithelium development |
| GO:0060324 | face development |
| GO:0007565 | female pregnancy |
| GO:0007281 | germ cell development |
| GO:0048732 | gland development |
| GO:0002068 | glandular epithelial cell development |
| GO:0003417 | growth plate cartilage development |
| GO:0021766 | hippocampus development |
| GO:0009755 | hormone-mediated signaling pathway |
| GO:0060173 | limb development |
| GO:0001889 | liver development |
| GO:0008584 | male gonad development |
| GO:0007275 | multicellular organism development |
| GO:0035264 | multicellular organism growth |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0061037 | negative regulation of cartilage development |
| GO:0045596 | negative regulation of cell differentiation |
| GO:0008285 | negative regulation of cell population proliferation |
| GO:0010629 | negative regulation of gene expression |
| GO:0030853 | negative regulation of granulocyte differentiation |
| GO:0032689 | negative regulation of interferon-gamma production |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0045892 | negative regulation of transcription, DNA-templated |
| GO:0017148 | negative regulation of translation |
| GO:0045947 | negative regulation of translational initiation |
| GO:0032720 | negative regulation of tumor necrosis factor production |
| GO:0001843 | neural tube closure |
| GO:0003148 | outflow tract septum morphogenesis |
| GO:0051099 | positive regulation of binding |
| GO:0045787 | positive regulation of cell cycle |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0010628 | positive regulation of gene expression |
| GO:0032736 | positive regulation of interleukin-13 production |
| GO:0032753 | positive regulation of interleukin-4 production |
| GO:0032754 | positive regulation of interleukin-5 production |
| GO:0045666 | positive regulation of neuron differentiation |
| GO:0045630 | positive regulation of T-helper 2 cell differentiation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0045893 | positive regulation of transcription, DNA-templated |
| GO:0030850 | prostate gland development |
| GO:0006468 | protein phosphorylation |
| GO:0042981 | regulation of apoptotic process |
| GO:0030852 | regulation of granulocyte differentiation |
| GO:0031641 | regulation of myelination |
| GO:0048167 | regulation of synaptic plasticity |
| GO:0006355 | regulation of transcription, DNA-templated |
| GO:0034097 | response to cytokine |
| GO:0032355 | response to estradiol |
| GO:0045471 | response to ethanol |
| GO:0033993 | response to lipid |
| GO:0032526 | response to retinoic acid |
| GO:0033189 | response to vitamin A |
| GO:0048384 | retinoic acid receptor signaling pathway |
| GO:0060010 | Sertoli cell fate commitment |
| GO:0007165 | signal transduction |
| GO:0007283 | spermatogenesis |
| GO:0060534 | trachea cartilage development |
| GO:0001657 | ureteric bud development |
| GO:0055012 | ventricular cardiac muscle cell differentiation |