| Tag | Content |
|---|---|
| Uniprot ID | G1TI43 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSOCUP00000016610 |
| Ensembl nucleotide ID | ENSOCUG00000004903 |
| Gene name | Retinoic acid receptor alpha |
| Gene symbol | RARA |
| Organism | Oryctolagus cuniculus |
| NCBI taxa ID | 9986 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | |
| Sequence | MASNSSSCPT PGGGHLNGYP VPPYAFFFPP MLGGLSPPGA LTTLQHQLPV SGYSTPSPAT 60 IETQSSSSEE IVPSPPSPPP LPRIYKPCFV CQDKSSGYHY GVSACEGCKG FFRRSIQKNM 120 VYTCHRDKNC IINKVTRNRC QYCRLQKCFE VGMSKESVRN DRNKKKKEAP KPECSESYTL 180 TPEVGELIEK VRKAHQETFP ALCQLGKYTT NNSSEQRVSL DIDLWDKFSE LSTKCIIKTV 240 EFAKQLPGFT TLTIADQITL LKAACLDILI LRICTRYTPE QDTMTFSDGL TLNRTQMHNA 300 GFGPLTDLVF AFANQLLPLE MDDAETGLLS AICLICGDRQ DLEQPDRVDM LQEPLLEALK 360 VYVRKRRPSR PHMFPKMLMK ITDLRSISAK GAERVITLKM EIPGSMPPLI QEMLENSEGL 420 DTLSGQQGGG GRDEGGLGPP PGSCSPSLSP SSNRSSPATH SP 462 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | RARA | 534280 | F1MWQ3 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | RARA | 102188350 | A0A452EMU9 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | RARA | 5914 | P10276 | CPO,CL/P | Homo sapiens | Publication | More>> | |
| 1:1 ortholog | Rara | 19401 | P11416 | CPO | E14.5 | Mus musculus | Publication | More>> |
| 1:1 ortholog | RARA | 454647 | A0A2J8KGL7 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | RARA | 396709 | A0A480PNE7 | Sus scrofa | Prediction | More>> | ||
| 1:1 ortholog | RARA | G1TI43 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Rara | 24705 | A0A0G2JW78 | Rattus norvegicus | Prediction | More>> | ||
| 1:1 ortholog | raraa | 30680 | T2DKU4 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0015629 | actin cytoskeleton |
| GO:0005829 | cytosol |
| GO:0042025 | host cell nucleus |
| GO:0000790 | nuclear chromatin |
| GO:0005654 | nucleoplasm |
| GO:0051393 | alpha-actinin binding |
| GO:0031490 | chromatin DNA binding |
| GO:0004879 | nuclear receptor activity |
| GO:0019904 | protein domain specific binding |
| GO:0051018 | protein kinase A binding |
| GO:0043422 | protein kinase B binding |
| GO:0001972 | retinoic acid binding |
| GO:0044323 | retinoic acid-responsive element binding |
| GO:0005102 | signaling receptor binding |
| GO:0003707 | steroid hormone receptor activity |
| GO:0003713 | transcription coactivator activity |
| GO:0003714 | transcription corepressor activity |
| GO:0008134 | transcription factor binding |
| GO:0008270 | zinc ion binding |
| GO:0043277 | apoptotic cell clearance |
| GO:0071391 | cellular response to estrogen stimulus |
| GO:0071222 | cellular response to lipopolysaccharide |
| GO:0071300 | cellular response to retinoic acid |
| GO:0060591 | chondroblast differentiation |
| GO:0031076 | embryonic camera-type eye development |
| GO:0060324 | face development |
| GO:0007281 | germ cell development |
| GO:0002068 | glandular epithelial cell development |
| GO:0003417 | growth plate cartilage development |
| GO:0060173 | limb development |
| GO:0035264 | multicellular organism growth |
| GO:0043066 | negative regulation of apoptotic process |
| GO:0061037 | negative regulation of cartilage development |
| GO:0030853 | negative regulation of granulocyte differentiation |
| GO:0032689 | negative regulation of interferon-gamma production |
| GO:0000122 | negative regulation of transcription by RNA polymerase II |
| GO:0032720 | negative regulation of tumor necrosis factor production |
| GO:0001843 | neural tube closure |
| GO:0003148 | outflow tract septum morphogenesis |
| GO:0051099 | positive regulation of binding |
| GO:0045787 | positive regulation of cell cycle |
| GO:0008284 | positive regulation of cell population proliferation |
| GO:0032736 | positive regulation of interleukin-13 production |
| GO:0032753 | positive regulation of interleukin-4 production |
| GO:0032754 | positive regulation of interleukin-5 production |
| GO:0045630 | positive regulation of T-helper 2 cell differentiation |
| GO:0045944 | positive regulation of transcription by RNA polymerase II |
| GO:0006468 | protein phosphorylation |
| GO:0048384 | retinoic acid receptor signaling pathway |
| GO:0060010 | Sertoli cell fate commitment |
| GO:0007283 | spermatogenesis |
| GO:0060534 | trachea cartilage development |
| GO:0001657 | ureteric bud development |
| GO:0055012 | ventricular cardiac muscle cell differentiation |