Gene: Inhbb

Basic information

Tag Content
Uniprot ID A0A0G2K0C6
Entrez ID
Genbank protein ID
Genbank nucleotide ID
Ensembl protein ID ENSRNOP00000071390
Ensembl nucleotide ID ENSRNOG00000060237
Gene name Inhibin beta B chain
Gene symbol Inhbb
Organism Rattus norvegicus
NCBI taxa ID 10116
Cleft type
Developmental stage
Data sources Homology search
Reference
Functional description
Sequence
PGRALGAACL LLLAAGWLGP EAWGSPTPPP SPAAPPPPPP PGAPGGSQDT CTSCGGGGGG 60
FRRPEELGRV DGDFLEAVKR HILSRLQLRG RPNITHAVPK AAMVTALRKL HAGKVREDGR 120
VEIPHLDGHA SPGADGQERV SEIISFAETD GLASSRVRLY FFVSNEGNQN LFVVQASLWL 180
YLKLLPYVLE KGSRRKVRVK VYFQEQGHGD RWNVVEKKVD LKRSGWHTFP ITEAIQALFE 240
RGERRLNLDV QCDSCQELAV VPVFVDPGEE SHRPFVVVQA RLGDSRHRIR KRGLECDGRT 300
SLCCRQQFFI DFRLIGWNDW IIAPTGYYGN YCEGSCPAYL AGVPGSASSF HTAVVNQYRM 360
RGLNPGPVNS CCIPTKLSSM SMLYFDDEYN IVKRDVPNMI VEECGCA 407

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologINHBB530430A0A3Q1LMU4Bos taurusPredictionMore>>
1:1 orthologINHBB100861250A0A452FXK8Capra hircusPredictionMore>>
1:1 orthologINHBB3625P09529Homo sapiensPredictionMore>>
1:1 orthologInhbb16324Q04999CPOMus musculusPublicationMore>>
1:1 orthologINHBB470524A0A2I3TNV9Pan troglodytesPredictionMore>>
1:1 orthologINHBBA0A287BPF5Sus scrofaPredictionMore>>
1:1 orthologINHBBG1SN71Oryctolagus cuniculusPredictionMore>>
1:1 orthologInhbbA0A0G2K0C6Rattus norvegicusPredictionMore>>
1:1 orthologLOC100332902100332902A0A0G2KD75Danio rerioPredictionMore>>

Gene ontology

GO ID GO Term
GO:0071944 cell periphery
GO:0005576 extracellular region
GO:0048471 perinuclear region of cytoplasm
GO:0008083 growth factor activity
GO:0005179 hormone activity
GO:0042803 protein homodimerization activity
GO:0032924 activin receptor signaling pathway
GO:0032869 cellular response to insulin stimulus
GO:0044320 cellular response to leptin stimulus
GO:0009267 cellular response to starvation
GO:0045444 fat cell differentiation
GO:0046882 negative regulation of follicle-stimulating hormone secretion
GO:0048178 negative regulation of hepatocyte growth factor biosynthetic process
GO:0046676 negative regulation of insulin secretion
GO:0048599 oocyte development
GO:2001235 positive regulation of apoptotic signaling pathway
GO:0046881 positive regulation of follicle-stimulating hormone secretion
GO:0060279 positive regulation of ovulation
GO:0009611 response to wounding

Functional annotations

Keywords

Keyword ID Keyword Term
KW-1015 Disulfide bond
KW-0339 Growth factor
KW-1185 Reference proteome
KW-0964 Secreted
KW-0732 Signal

Interpro

InterPro ID InterPro Term
IPR029034 Cystine-knot_cytokine
IPR000381 Inhibin_betaB
IPR001839 TGF-b_C
IPR001111 TGF-b_propeptide
IPR015615 TGF-beta-rel
IPR017948 TGFb_CS

PROSITE

PROSITE ID PROSITE Term
PS00250 TGF_BETA_1
PS51362 TGF_BETA_2

Pfam

Pfam ID Pfam Term
PF00019 TGF_beta
PF00688 TGFb_propeptide