| Tag | Content |
|---|---|
| Uniprot ID | A0A0G2KD75 |
| Entrez ID | 100332902 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_005172936.3 |
| Ensembl protein ID | ENSDARP00000130239 |
| Ensembl nucleotide ID | ENSDARG00000103892 |
| Gene name | Activin beta-B chain |
| Gene symbol | LOC100332902 |
| Organism | Danio rerio |
| NCBI taxa ID | 7955 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. |
| Sequence | SFLSITDDSL TSKTSLFFII SNEGNQNLHV SQANLWLYFK LLPSALEKGS RRKVTVKVYS 60 QEPGVGSKWN LVEKRVDLKR SGWHTFPLTD AVQMVFSQGD RRQNLDVRCE GCEKMGVVPI 120 LVNSADESHR PFLVVQARVA DNKHRIRKRG LECDGSNSLC CRQQFYIDFR LIGWNDWIIA 180 PSGYFGNYCE GNCPAYMAGV PGSASSFHTA VVNQYRMRGM SPGSMNSCCI PTKLSTMSML 240 YFDDEYNIVK RDVPNMIVEE CGCA 264 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | INHBB | 530430 | A0A3Q1LMU4 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | INHBB | 100861250 | A0A452FXK8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | INHBB | 3625 | P09529 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Inhbb | 16324 | Q04999 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | INHBB | 470524 | A0A2I3TNV9 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | INHBB | A0A287BPF5 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | INHBB | G1SN71 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Inhbb | A0A0G2K0C6 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | LOC100332902 | 100332902 | A0A0G2KD75 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005615 | extracellular space |
| GO:0005125 | cytokine activity |
| GO:0008083 | growth factor activity |
| GO:0005179 | hormone activity |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation |
| GO:0060395 | SMAD protein signal transduction |
| Pfam ID | Pfam Term |
|---|---|
| PF00019 | TGF_beta |