| Tag | Content |
|---|---|
| Uniprot ID | Q04999; Q3V1N0; Q61277; Q80VC4; |
| Entrez ID | 16324 |
| Genbank protein ID | CAA49326.1; CAA58290.1; AAH48845.1; BAE21120.1; |
| Genbank nucleotide ID | NM_008381.4 |
| Ensembl protein ID | ENSMUSP00000044918 |
| Ensembl nucleotide ID | ENSMUSG00000037035 |
| Gene name | Inhibin beta B chain |
| Gene symbol | Inhbb |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 7885473 |
| Functional description | Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. |
| Sequence | MDGLPGRALG AACLLLLVAG WLGPEAWGSP TPPPSPAAPP PPPPPGAPGG SQDTCTSCGG 60 GGGGFRRPEE LGRVDGDFLE AVKRHILSRL QLRGRPNITH AVPKAAMVTA LRKLHAGKVR 120 EDGRVEIPHL DGHASPGADG QERVSEIISF AETDGLASSR VRLYFFVSNE GNQNLFVVQA 180 SLWLYLKLLP YVLEKGSRRK VRVKVYFQEQ GHGDRWNVVE KKVDLKRSGW HTFPITEAIQ 240 ALFERGERRL NLDVQCDSCQ ELAVVPVFVD PGEESHRPFV VVQARLGDSR HRIRKRGLEC 300 DGRTSLCCRQ QFFIDFRLIG WNDWIIAPTG YYGNYCEGSC PAYLAGVPGS ASSFHTAVVN 360 QYRMRGLNPG PVNSCCIPTK LSSMSMLYFD DEYNIVKRDV PNMIVEECGC A 411 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | INHBB | 530430 | A0A3Q1LMU4 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | INHBB | 100861250 | A0A452FXK8 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | INHBB | 3625 | P09529 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Inhbb | 16324 | Q04999 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | INHBB | 470524 | A0A2I3TNV9 | Pan troglodytes | Prediction | More>> | ||
| 1:1 ortholog | INHBB | A0A287BPF5 | Sus scrofa | Prediction | More>> | |||
| 1:1 ortholog | INHBB | G1SN71 | Oryctolagus cuniculus | Prediction | More>> | |||
| 1:1 ortholog | Inhbb | A0A0G2K0C6 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | LOC100332902 | 100332902 | A0A0G2KD75 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005125 | cytokine activity | IBA |
| GO:0005179 | hormone activity | IEA |
| GO:0008083 | growth factor activity | IEA |
| GO:0034711 | inhibin binding | ISO |
| GO:0042803 | protein homodimerization activity | ISS |
| GO:0042803 | protein homodimerization activity | ISO |
| GO:0044877 | protein-containing complex binding | ISO |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0001654 | eye development | TAS |
| GO:0009267 | cellular response to starvation | IEP |
| GO:0009611 | response to wounding | ISS |
| GO:0010862 | positive regulation of pathway-restricted SMAD protein phosphorylation | IBA |
| GO:0032869 | cellular response to insulin stimulus | IEP |
| GO:0032924 | activin receptor signaling pathway | ISS |
| GO:0032924 | activin receptor signaling pathway | ISO |
| GO:0044320 | cellular response to leptin stimulus | IEP |
| GO:0045444 | fat cell differentiation | IEP |
| GO:0046676 | negative regulation of insulin secretion | IMP |
| GO:0046881 | positive regulation of follicle-stimulating hormone secretion | ISS |
| GO:0046881 | positive regulation of follicle-stimulating hormone secretion | ISO |
| GO:0046882 | negative regulation of follicle-stimulating hormone secretion | ISS |
| GO:0046882 | negative regulation of follicle-stimulating hormone secretion | ISO |
| GO:0048178 | negative regulation of hepatocyte growth factor biosynthetic process | ISS |
| GO:0048178 | negative regulation of hepatocyte growth factor biosynthetic process | ISO |
| GO:0048599 | oocyte development | IGI |
| GO:0060279 | positive regulation of ovulation | IMP |
| GO:0060395 | SMAD protein signal transduction | IBA |
| GO:0071397 | cellular response to cholesterol | ISO |
| GO:2001235 | positive regulation of apoptotic signaling pathway | IGI |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005576 | extracellular region | TAS |
| GO:0005615 | extracellular space | ISO |
| GO:0005615 | extracellular space | IBA |
| GO:0005615 | extracellular space | HDA |
| GO:0043513 | inhibin B complex | ISO |
| GO:0048471 | perinuclear region of cytoplasm | ISS |
| GO:0048471 | perinuclear region of cytoplasm | ISO |
| GO:0048471 | perinuclear region of cytoplasm | IDA |
| GO:0071944 | cell periphery | IDA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1502540 | Signaling by Activin | IEA |
| R-MMU-162582 | Signal Transduction | IEA |
| R-MMU-209822 | Glycoprotein hormones | IEA |
| R-MMU-209952 | Peptide hormone biosynthesis | IEA |
| R-MMU-2473224 | Antagonism of Activin by Follistatin | IEA |
| R-MMU-2980736 | Peptide hormone metabolism | IEA |
| R-MMU-392499 | Metabolism of proteins | IEA |
| R-MMU-9006936 | Signaling by TGF-beta family members | IEA |